A variety of knoevenagel compounds from isatin were synthesized using an eco-friendly methodology. It was used only the binary solvent ethanol: water (3:7 v/v) without the presence of metal catalyst what enabled the reaction between different isatins with malononitrile in a quick reaction time of 2–5 min and isolated yields 80–96%. When cyanoesters were used as methylene actives, the reactions were longer and the knoenevagel products were obtained 79–92% isolated yields.

中文翻译：

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仅使用生态友好型溶剂即可快速合成基于伊斯汀的诺文烯醇加合物

使用生态友好的方法合成了多种来自靛红的knoevenagel化合物。它仅使用二元溶剂乙醇：水（3：7 v / v），不存在金属催化剂，这使得不同的isatins与丙二腈之间的反应可以在2-5分钟的快速反应时间内完成，分离产率为80-96％ 。当使用氰基酯作为亚甲基活性剂时，反应时间更长，并且分离得到的knoenevagel产品的产率为79-92％。