Background

The drive to eliminate viral hepatitis by 2030 is underway. However, locally generated data on active infection is required to focus such efforts. We performed a regionally-inclusive survey to determine prevalence of active HCV, genotypes and related factors among Ugandan blood donor.

Methods

Participants from regional blood banks and blood collection centers were surveyed for information on demographic, clinical and lifestyle factors. Blood was assayed for HCV infection, HCV genotypes and subtypes. Logistic regression was done to determine factors associated with active HCV infection.

Results

Of 1243 participants, 1041 (83.7%) were male, average age (SD), 27.7 (9.8). Prevalence of active HCV infection was 7.8% and we identified 3 genotypes. Median age (adj. OR (95% CI) = 1.03 (1.01–1.06), p-value = 0.040)), Northern region of birth versus Central or Eastern (adj. OR (95% CI) = 10.25 (2.65–39.68), p-value = 0.001)), Northern residence, versus Central or Eastern (adj. OR (95% CI) = 0.23 (0.08–0.65), p-value = 0.006)), and being married (versus single/divorced) adj. OR 2.49(1.3–4.79), p-value = 0.006 were associated with active HCV infection.

Conclusion

Targeted interventions in at-risk populations coupled with linkage to care and treatment will help achieve WHO elimination goals in this setting.

中文翻译：

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乌干达的丙型肝炎：识别受感染的献血者以进行微量消除

背景

到 2030 年消除病毒性肝炎的努力正在进行中。但是，需要本地生成的有关活动性感染的数据来集中这些努力。我们进行了一项包括区域性的调查，以确定乌干达献血者中活动性 HCV 的患病率、基因型和相关因素。

方法

对来自地区血库和采血中心的参与者进行了关于人口统计学、临床和生活方式因素的调查。检测血液中的 HCV 感染、HCV 基因型和亚型。进行逻辑回归以确定与活动性 HCV 感染相关的因素。

结果

在 1243 名参与者中，1041 名 (83.7%) 为男性，平均年龄 (SD) 为 27.7 (9.8)。活动性 HCV 感染的患病率为 7.8%，我们确定了 3 种基因型。中位年龄（adj. OR (95% CI) = 1.03 (1.01–1.06), p-value = 0.040)），北部出生地区与中部或东部（adj. OR (95% CI) = 10.25 (2.65–39.68) ), p 值 = 0.001)), 北部居住地, 与中部或东部 (adj. OR (95% CI) = 0.23 (0.08–0.65), p 值 = 0.006)), 已婚 (相对于单身/离婚) 形容词。OR 2.49（1.3-4.79），p 值 = 0.006 与活动性 HCV 感染相关。

结论

对高危人群进行有针对性的干预，并与护理和治疗联系起来，将有助于在这种情况下实现世卫组织的消除目标。