Paclitaxel is a key member of the Taxane (Taxol/paclitaxel, docetaxel/taxotere) family of successful drugs used in the current treatment of several solid tumors, including ovarian cancer. The molecular target of Taxol/paclitaxel has been identified as tubulin, and paclitaxel binding alters the dynamics and thus stabilizes microtubule bundles. Traditionally, the anti-cancer mechanism of paclitaxel has been thought to originate from its interfering with the role of microtubules in mitosis, resulting in mitotic arrest and subsequent apoptosis. However, recent evidence suggests that paclitaxel operates in cancer therapies via an as-yet-undefined mechanism rather than as a mitotic inhibitor.

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核层粘连蛋白 A/C 表达是紫杉醇敏感性的关键决定因素

紫杉醇是紫杉烷（Taxol/paclitaxel、docetaxel/taxotere）家族的关键成员，该家族的成功药物目前用于治疗多种实体瘤，包括卵巢癌。紫杉醇/紫杉醇的分子靶点已被确定为微管蛋白，紫杉醇的结合改变了动力学，从而稳定了微管束。传统上认为紫杉醇的抗癌机制源于其干扰微管在有丝分裂中的作用，导致有丝分裂停滞和随后的细胞凋亡。然而，最近的证据表明，紫杉醇通过尚未确定的机制而不是作为有丝分裂抑制剂在癌症治疗中起作用。