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Comprehensive pregnancy monitoring with a network of wireless, soft, and flexible sensors in high- and low-resource health settings [Engineering]
Proceedings of the National Academy of Sciences of the United States of America ( IF 11.1 ) Pub Date : 2021-05-18 , DOI: 10.1073/pnas.2100466118
Dennis Ryu 1 , Dong Hyun Kim 1 , Joan T Price 2, 3 , Jong Yoon Lee 1, 4 , Ha Uk Chung 1, 4, 5 , Emily Allen 4 , Jessica R Walter 6 , Hyoyoung Jeong 4, 7 , Jingyue Cao 1 , Elena Kulikova 1 , Hajar Abu-Zayed 1, 4 , Rachel Lee 1, 4 , Knute L Martell 4 , Michael Zhang 4 , Brianna R Kampmeier 4 , Marc Hill 1 , JooHee Lee 1 , Edward Kim 1 , Yerim Park 1 , Hokyung Jang 4 , Hany Arafa 4, 8 , Claire Liu 4 , Maureen Chisembele 9, 10 , Bellington Vwalika 9 , Ntazana Sindano 3 , M Bridget Spelke 3 , Amy S Paller 11 , Ashish Premkumar 6, 12, 13 , William A Grobman 6 , Jeffrey S A Stringer 3, 14 , John A Rogers 4, 5, 7, 15, 16 , Shuai Xu 8, 11, 17
Affiliation  

Vital signs monitoring is a fundamental component of ensuring the health and safety of women and newborns during pregnancy, labor, and childbirth. This monitoring is often the first step in early detection of pregnancy abnormalities, providing an opportunity for prompt, effective intervention to prevent maternal and neonatal morbidity and mortality. Contemporary pregnancy monitoring systems require numerous devices wired to large base units; at least five separate devices with distinct user interfaces are commonly used to detect uterine contractility, maternal blood oxygenation, temperature, heart rate, blood pressure, and fetal heart rate. Current monitoring technologies are expensive and complex with implementation challenges in low-resource settings where maternal morbidity and mortality is the greatest. We present an integrated monitoring platform leveraging advanced flexible electronics, wireless connectivity, and compatibility with a wide range of low-cost mobile devices. Three flexible, soft, and low-profile sensors offer comprehensive vital signs monitoring for both women and fetuses with time-synchronized operation, including advanced parameters such as continuous cuffless blood pressure, electrohysterography-derived uterine monitoring, and automated body position classification. Successful field trials of pregnant women between 25 and 41 wk of gestation in both high-resource settings (n = 91) and low-resource settings (n = 485) demonstrate the system’s performance, usability, and safety.



中文翻译:

在高资源和低资源健康环境中使用无线、软和灵活的传感器网络进行全面的妊娠监测 [工程]

生命体征监测是确保妇女和新生儿在怀孕、分娩和分娩期间的健康和安全的基本组成部分。这种监测通常是早期发现妊娠异常的第一步,为及时有效的干预提供机会,以预防孕产妇和新生儿的发病率和死亡率。现代怀孕监测系统需要大量设备连接到大型基础单元;至少五个具有不同用户界面的独立设备通常用于检测子宫收缩力、母体血氧饱和度、温度、心率、血压和胎儿心率。目前的监测技术昂贵且复杂,在孕产妇发病率和死亡率最高的资源匮乏环境中实施挑战。我们展示了一个集成监控平台,该平台利用先进的柔性电子设备、无线连接以及与各种低成本移动设备的兼容性。三个灵活、柔软和低调的传感器通过时间同步操作为女性和胎儿提供全面的生命体征监测,包括连续无袖带血压、子宫电图衍生的子宫监测和自动体位分类等高级参数。在两个高资源环境中对妊娠 25 至 41 周的孕妇进行成功的田间试验(和低调传感器通过时间同步操作为女性和胎儿提供全面的生命体征监测,包括连续无袖带血压、子宫电图衍生的子宫监测和自动体位分类等高级参数。在两个高资源环境中对妊娠 25 至 41 周的孕妇进行成功的田间试验(和低调传感器通过时间同步操作为女性和胎儿提供全面的生命体征监测,包括连续无袖带血压、子宫电图衍生的子宫监测和自动体位分类等高级参数。在两个高资源环境中对妊娠 25 至 41 周的孕妇进行成功的田间试验(n = 91) 和低资源设置 ( n = 485) 展示了系统的性能、可用​​性和安全性。

更新日期:2021-05-11
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