ABSTRACT

Research studies exploring the association of cognitive complaints with objectively assessed cognitive decline report inconsistent results. However, many of these have methodological limitations. We investigated whether 1) more severe subjective cognitive decline (SCD) and subjective memory decline (SMD) predict change in objectively assessed global cognition, remote memory, recent memory, learning; 2) the predictive value of more severe SMD over change in objectively assessed remote memory, recent memory, and learning is stronger for individuals that report an SMD that started within the past five years than for those that report an SMD that started five or more years previously and/or stronger for those that experienced SMD within the past two years than for those who had not; and 3) greater depression and anxiety are associated with more severe SCD and SMD. We used two-year longitudinal data from the CFAS-Wales study (N = 1,531; mean (SD) age = 73.0 (6.0) years). We fitted linear regression models. More severe SCD and SMD did not predict change in objectively assessed global cognition, remote memory, and recent memory but predicted lower scores in learning. The prediction of SMD over change in learning was not stronger when individuals reported an SMD that started within the past five years compared to when they reported an SMD that started five or more years previously nor when individuals reported an SMD that started within the past two years than those who did not. Greater depression and anxiety were associated with more severe SCD and SMD. More severe SMD may be useful for predicting lower learning ability and for identifying individuals experiencing depression and anxiety.

摘要

探索认知抱怨与客观评估的认知下降之间关联的研究报告不一致的结果。然而，其中许多有方法上的限制。我们调查了 1) 更严重的主观认知衰退 (SCD) 和主观记忆衰退 (SMD) 是否能预测客观评估的全局认知、远程记忆、近期记忆、学习的变化；2) 更严重的 SMD 对客观评估的远程记忆、近期记忆和学习变化的预测值对于报告在过去五年内开始的 SMD 的个人比报告开始五年或更长时间的 SMD 的个人更强过去两年内经历过 SMD 的人比没有经历过 SMD 的人以前和/或更强；3) 更大的抑郁和焦虑与更严重的 SCD 和 SMD 相关。我们使用了来自 CFAS-Wales 研究的两年纵向数据（N = 1,531；平均 (SD) 年龄 = 73.0 (6.0) 岁）。我们拟合了线性回归模型。更严重的 SCD 和 SMD 并不能预测客观评估的全局认知、远程记忆和近期记忆的变化，但预测学习分数较低。当个人报告在过去五年内开始的 SMD 与他们报告在五年或五年前开始的 SMD 或当个人报告在过去两年内开始的 SMD 相比时，SMD 对学习变化的预测并不更强比那些没有的人。更严重的抑郁和焦虑与更严重的 SCD 和 SMD 相关。