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Perspectives on formaldehyde dysregulation: Mitochondrial DNA damage and repair in mammalian cells
DNA Repair ( IF 3.8 ) Pub Date : 2021-05-11 , DOI: 10.1016/j.dnarep.2021.103134
Cristina A Nadalutti 1 , Rajendra Prasad 1 , Samuel H Wilson 1
Affiliation  

Maintaining genome stability involves coordination between different subcellular compartments providing cells with DNA repair systems that safeguard against environmental and endogenous stresses. Organisms produce the chemically reactive molecule formaldehyde as a component of one-carbon metabolism, and cells maintain systems to regulate endogenous levels of formaldehyde under physiological conditions, preventing genotoxicity, among other adverse effects. Dysregulation of formaldehyde is associated with several diseases, including cancer and neurodegenerative disorders. In the present review, we discuss the complex topic of endogenous formaldehyde metabolism and summarize advances in research on fo dysregulation, along with future research perspectives.



中文翻译:

甲醛失调的观点:哺乳动物细胞中的线粒体 DNA 损伤和修复

维持基因组稳定性涉及不同亚细胞区室之间的协调,为细胞提供 DNA 修复系统,以抵御环境和内源性压力。生物体产生化学反应分子甲醛作为单碳代谢的组成部分,细胞维持系统以在生理条件下调节内源性甲醛水平,防止遗传毒性以及其他不利影响。甲醛的失调与多种疾病有关,包括癌症和神经退行性疾病。在本综述中,我们讨论了内源性甲醛代谢的复杂主题,并总结了 fo 失调的研究进展,以及未来的研究前景。

更新日期:2021-06-09
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