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Integration of mechanics and biology in computer simulation of bone remodeling
Progress in Biophysics and Molecular Biology ( IF 3.8 ) Pub Date : 2021-05-28 , DOI: 10.1016/j.pbiomolbio.2021.05.001
Anup Pant 1 , Elliot Paul 1 , Glen L Niebur 2 , Ali Vahdati 1
Affiliation  

Bone remodeling is a complex physiological process that spans across multiple spatial and temporal scales and is regulated by both mechanical and hormonal cues. An imbalance between bone resorption and bone formation in the process of bone remodeling may lead to various bone pathologies. One powerful and non-invasive approach to gain new insights into mechano-adaptive bone remodeling is computer modeling and simulation. Recent findings in bone physiology and advances in computer modeling have provided a unique opportunity to study the integration of mechanics and biology in bone remodeling. Our objective in this review is to critically appraise recent advances and developments and discuss future research opportunities in computational bone remodeling approaches that enable integration of mechanics and cellular and molecular pathways. Based on the critical appraisal of the relevant recent published literature, we conclude that multiscale in silico integration of personalized bone mechanics and mechanobiology combined with data science and analytics techniques offer the potential to deepen our knowledge of bone remodeling and provide ample opportunities for future research.



中文翻译:

力学和生物学在骨重建计算机模拟中的整合

骨重塑是一个复杂的生理过程,跨越多个空间和时间尺度,并受机械和荷尔蒙信号的调节。骨重塑过程中骨吸收和骨形成之间的不平衡可能导致各种骨病变。计算机建模和模拟是一种强大且非侵入性的方法,可用于获得对机械适应性骨重建的新见解。骨骼生理学的最新发现和计算机建模的进步为研究力学和生物学在骨骼重塑中的整合提供了独特的机会。我们在这篇综述中的目标是批判性地评估最近的进展和发展,并讨论计算骨重建方法的未来研究机会,这些方法能够整合力学与细胞和分子途径。个性化骨力学和力学生物学的计算机集成与数据科学和分析技术相结合,为加深我们对骨骼重塑的知识提供了潜力,并为未来的研究提供了充足的机会。

更新日期:2021-07-22
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