ObjectiveTo discuss the psychiatric symptoms that are associated with CADASIL syndrome Cerebral:Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is a rare type of hereditary disease involving the small cerebral vessels. The clinical symptoms are various and include recurrent ischemic strokes, migraine with aura, seizures with epilepsy, psychiatric problems such as mood disturbances, and progressive cognitive decline leading to dementia. This disease needs awareness amongst the psychiatrists even though it is discussed much more in neurology literature. Psychiatric symptoms are seen in 20–41% of patients with CADASIL syndrome (1, 2). Psychiatric symptoms are actually the initial presentation in 15% of the cases. (3) The psychiatric disturbance most reported are mood disturbances (9–41%) especially depression. Here a 42-year-old African American female was brought to the hospital emergency room after she was found wandering in the streets. Psychiatry was consulted for altered mental status. Upon evaluation by the psychiatric consult service she was only oriented to person, depressed, anxious and complaining of headaches. Initial CT scan showed marked small vessel disease and old lacunar infarcts in the basal ganglia and right corona radiata. Magnetic Resonance Imaging (MRI) of the brain showed acute infarcts in the right posterior frontal and right parietal lobes along with old infarcts. Her symptoms and findings on imaging were consistent with CADASIL syndrome. Once the diagnosis was confirmed and prior records were obtained patient was resumed on an antidepressant and anxiolytic.ConclusionThe purpose of this case report was to discuss psychiatric symptoms associated with CADASIL syndrome. Although there has been research showing a relationship between vascular disease and depression, a review of the literature suggests that there needs to be more research done to explore other psychiatric disturbances that may be seen with this syndrome. Psychiatric symptoms that are untreated can have the potential to further impact the quality of life therefore psychiatrists need to be aware of this syndrome in order to treat these patients promptly.References1 https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-017-0778-8 2 http://dx.doi.org/10.32474/OJNBD.2018.01.000101 3 https://pdfs.semanticscholar.org/47f6/5952ee3c5dcf2a61345f704914b17fa8dc0d.pdf

中文翻译：

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与 CADASIL 综合征相关的情绪症状：病例报告

目的探讨与CADASIL综合征相关的精神症状。临床症状多种多样，包括复发性缺血性中风、先兆偏头痛、癫痫发作、情绪障碍等精神问题以及导致痴呆的进行性认知衰退。尽管在神经病学文献中对其进行了更多的讨论，但这种疾病需要精神科医生的认识。20-41% 的 CADASIL 综合征患者出现精神症状 (1, 2)。精神症状实际上是 15% 病例的初始表现。(3) 报告最多的精神障碍是情绪障碍（9-41%），尤其是抑郁症。在这里，一名 42 岁的非裔美国女性被发现在街上徘徊后被送往医院急诊室。精神病学被咨询以改变精神状态。经精神科咨询服务评估后，她只面向人，抑郁、焦虑和抱怨头痛。最初的 CT 扫描显示基底节和右侧放射冠有明显的小血管病变和陈旧性腔隙梗塞。大脑的磁共振成像 (MRI) 显示右后额叶和右顶叶急性梗塞以及陈旧性梗塞。她的症状和影像学检查结果与 CADASIL 综合征一致。一旦诊断得到确认并获得了先前的记录，患者就会恢复使用抗抑郁药和抗焦虑药。结论本病例报告的目的是讨论与 CADASIL 综合征相关的精神症状。尽管有研究表明血管疾病和抑郁症之间存在关系，但对文献的回顾表明，需要进行更多的研究来探索这种综合征可能出现的其他精神障碍。未经治疗的精神症状可能会进一步影响生活质量，因此精神科医生需要了解这种综合征，以便及时治疗这些患者。参考文献1 https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916- 017-0778-8 2 http://dx.doi.org/10.32474/OJNBD.2018.01.000101 3 https://pdfs.semanticscholar。