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Old age genetically confirmed frontotemporal lobar degeneration with TDP-43 has limbic predominant TDP-43 deposition
Neuropathology and Applied Neurobiology ( IF 5 ) Pub Date : 2021-05-09 , DOI: 10.1111/nan.12727 Marina Buciuc 1 , Jennifer L Whitwell 2 , Matthew C Baker 3 , Rosa Rademakers 3 , Dennis W Dickson 3 , Keith A Josephs 1
Neuropathology and Applied Neurobiology ( IF 5 ) Pub Date : 2021-05-09 , DOI: 10.1111/nan.12727 Marina Buciuc 1 , Jennifer L Whitwell 2 , Matthew C Baker 3 , Rosa Rademakers 3 , Dennis W Dickson 3 , Keith A Josephs 1
Affiliation
To assess the burden of transactive response DNA-binding protein of 43 kDa (TDP-43) inclusions in a unique cohort of old-age patients with genetic frontotemporal lobar degeneration (gFTLD-TDP) and compare these patients with sporadic old-age individuals with TDP-43, either in the presence of Alzheimer's disease (AD-TDP) or in isolation (pure-TDP).
中文翻译:
老年基因证实 TDP-43 的额颞叶变性具有边缘为主的 TDP-43 沉积
评估 43 kDa (TDP-43) 包涵体的反式反应 DNA 结合蛋白在一个独特的遗传性额颞叶变性 (gFTLD-TDP) 老年患者队列中的负担,并将这些患者与散发性老年个体进行比较TDP-43,无论是在阿尔茨海默病 (AD-TDP) 存在下还是单独存在时 (纯 TDP)。
更新日期:2021-05-09
中文翻译:
老年基因证实 TDP-43 的额颞叶变性具有边缘为主的 TDP-43 沉积
评估 43 kDa (TDP-43) 包涵体的反式反应 DNA 结合蛋白在一个独特的遗传性额颞叶变性 (gFTLD-TDP) 老年患者队列中的负担,并将这些患者与散发性老年个体进行比较TDP-43,无论是在阿尔茨海默病 (AD-TDP) 存在下还是单独存在时 (纯 TDP)。