There have been no published studies examining the epidemiology of Guillain-Barré syndrome (GBS) in large populations in Thailand. This study aimed to explore the incidence, patient characteristics, seasonality, treatments, and outcomes of GBS in Thailand. The National Health Security Office (NHSO) provided data on in-patient admission between fiscal year 2005 and 2017. We selected all patients with a primary diagnosis of GBS. We retrieved data regarding the total population from the Department of Provincial Administration. A total of 4521 patients with GBS were included. The median age was 42 years (IQR 22-56), and 61.5% were male. The incidence rate increased from 0.48 to 0.93 per 100 000 population over the 13 years. The incidence was increased with age and a male-to-female ratio of 1.6:1. There was seasonal variation in the rate of admission for GBS, with significantly more patients admitted in rainy vs summer (IRR 1.94, 95%CI 1.80-2.10, P < .001) and winter vs summer (IRR 1.48, 95%CI 1.36-1.60, P < .001). Treatment with IVIg increased from 4.4% to 29.6% (P < .001), whereas plasmapheresis decreased significantly from 4% to 1.32% (P = .017). The mortality rate was 3.5%. Elderly and young adults had a significantly higher mortality rate when compared to children and teenagers (P < .001 and P = .003). The incidence of GBS in Thailand was steady over 13 years and was greater in rainy and winter season. Treatment with IVIg increased while plasmapheresis decreased. Mortality was higher in elderly patients.

中文翻译：

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13 年来（2005-2017 年）泰国格林-巴利综合征的流行病学：一项全国性的基于人群的回顾性队列研究

尚无已发表的研究检查泰国大量人群中格林-巴利综合征 (GBS) 的流行病学。本研究旨在探讨泰国 GBS 的发病率、患者特征、季节性、治疗和结果。国家卫生安全办公室 (NHSO) 提供了 2005 至 2017 财年的住院数据。我们选择了所有初步诊断为 GBS 的患者。我们从省行政厅检索了有关总人口的数据。共纳入 4521 名 GBS 患者。中位年龄为 42 岁（IQR 22-56），61.5% 为男性。在过去的 13 年里，发病率从每 10 万人中的 0.48 人增加到 0.93 人。发病率随年龄增长而增加，男女比例为1.6:1。P  < .001) 和冬季与夏季 (IRR 1.48, 95%CI 1.36-1.60, P  < .001)。IVIg 治疗从 4.4% 增加到 29.6% ( P  < .001)，而血浆置换从 4% 显着下降到 1.32% ( P  = .017)。死亡率为3.5%。与儿童和青少年相比，老年人和年轻人的死亡率明显更高（P  < .001 和P  = .003）。泰国 GBS 的发病率在 13 年内保持稳定，雨季和冬季发病率更高。IVIg 治疗增加，而血浆置换减少。老年患者的死亡率更高。