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Melatonin and the health of menopausal women: A systematic review
Journal of Pineal Research ( IF 10.3 ) Pub Date : 2021-05-09 , DOI: 10.1111/jpi.12743
Yulia Treister-Goltzman 1, 2 , Roni Peleg 1, 2
Affiliation  

Melatonin is involved in multiple changes that characterize the aging and can potentially be a safe and effective treatment for menopausal women. The aim of this study was to carry out a systematic review of the medical literature on the health benefits of oral melatonin administration on menopausal women. The electronic databases PubMed, Scopus, and Web of Science were searched systematically on interventional studies that evaluated the association between oral melatonin administration and the health of menopausal women. Risk for bias was assessed for randomized, controlled studies by the RoB v.2 tool and for non-randomized trials by the ROBINS-I tool. Twenty-four studies on melatonin treatment in various aspects of women's health were included in the final systematic review. The studies included 1,173 participants. No evidence was found for an independent effect of melatonin on hemodynamic measures or markers of glucose metabolism. There is some evidence that very low-density lipoprotein and triglycerides levels increase during melatonin administration. There is a fair amount of evidence that melatonin treatment has a favorable effect on bone density and BMI. Melatonin treatment improves EEG patterns and subjective sleep quality in postmenopausal women with preexisting sleep impairment. In a dose of 3 mg and above, melatonin improves climacteric symptoms in one or more domains. The vast majority of the studies had a low risk for bias. In light of multiple health benefits and an excellent safety profile, melatonin administration should be considered in menopausal women.

中文翻译:

褪黑激素与更年期妇女的健康:系统评价

褪黑激素参与了表征衰老的多种变化,并可能成为更年期妇女安全有效的治疗方法。本研究的目的是对有关口服褪黑激素对绝经期妇女的健康益处的医学文献进行系统评价。对电子数据库 PubMed、Scopus 和 Web of Science 进行了系统搜索,以评估评估口服褪黑激素与更年期妇女健康之间关系的干预研究。使用 RoB v.2 工具评估随机对照研究和使用 ROBINS-I 工具评估非随机试验的偏倚风险。最终系统评价纳入了 24 项关于褪黑激素治疗女性健康各个方面的研究。这些研究包括 1,173 名参与者。没有发现褪黑激素对血流动力学测量或葡萄糖代谢标志物的独立影响的证据。有一些证据表明,在褪黑激素给药期间,极低密度脂蛋白和甘油三酯水平会升高。有大量证据表明褪黑激素治疗对骨密度和 BMI 有良好的影响。褪黑激素治疗可改善已存在睡眠障碍的绝经后妇女的脑电图模式和主观睡眠质量。在 3 毫克及以上的剂量下,褪黑激素可改善一个或多个领域的更年期症状。绝大多数研究的偏倚风险较低。鉴于多种健康益处和出色的安全性,应考虑在绝经期妇女中使用褪黑激素。有一些证据表明,在褪黑激素给药期间,极低密度脂蛋白和甘油三酯水平会升高。有大量证据表明褪黑激素治疗对骨密度和 BMI 有良好的影响。褪黑激素治疗可改善已存在睡眠障碍的绝经后妇女的脑电图模式和主观睡眠质量。在 3 毫克及以上的剂量下,褪黑激素可改善一个或多个领域的更年期症状。绝大多数研究的偏倚风险较低。鉴于多种健康益处和出色的安全性,应考虑在绝经期妇女中使用褪黑激素。有一些证据表明,在褪黑激素给药期间,极低密度脂蛋白和甘油三酯水平会升高。有大量证据表明褪黑激素治疗对骨密度和 BMI 有良好的影响。褪黑激素治疗可改善已存在睡眠障碍的绝经后妇女的脑电图模式和主观睡眠质量。在 3 毫克及以上的剂量下,褪黑激素可改善一个或多个领域的更年期症状。绝大多数研究的偏倚风险较低。鉴于多种健康益处和出色的安全性,应考虑在绝经期妇女中使用褪黑激素。有大量证据表明褪黑激素治疗对骨密度和 BMI 有良好的影响。褪黑激素治疗可改善已存在睡眠障碍的绝经后妇女的脑电图模式和主观睡眠质量。在 3 毫克及以上的剂量下,褪黑激素可改善一个或多个领域的更年期症状。绝大多数研究的偏倚风险较低。鉴于多种健康益处和出色的安全性,应考虑在绝经期妇女中使用褪黑激素。有大量证据表明褪黑激素治疗对骨密度和 BMI 有良好的影响。褪黑激素治疗可改善已存在睡眠障碍的绝经后妇女的脑电图模式和主观睡眠质量。在 3 毫克及以上的剂量下,褪黑激素可改善一个或多个领域的更年期症状。绝大多数研究的偏倚风险较低。鉴于多种健康益处和出色的安全性,应考虑在绝经期妇女中使用褪黑激素。
更新日期:2021-05-09
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