Given the highly polymorphic nature of Human Leukocyte Antigen (HLA) molecules, it is not surprising that they function as key regulators of the host immune response to almost all invading pathogens, including SARS-CoV-2, the etiological agent responsible for the recent COVID-19 pandemic. Several correlations have already been established between the expression of a specific HLA allele/haplotype and susceptibility/progression of SARS-CoV-2 infection and new ones are continuously emerging. Protective and harmful HLA variants have been described in both mild and severe forms of the disease, but considering the huge amount of existing variants, the data gathered in such a brief span of time are to some extent confusing and contradictory. The aim of this mini-review is to provide a snap-shot of the main findings so far collected on the HLA-SARS-CoV-2 interaction, so as to partially untangle this intricate yarn. As key factors in the generation of antigenic peptides to be presented by HLA molecules, ERAP1 and ERAP2 role in SARS-CoV-2 infection will be revised as well.

鉴于人类白细胞抗原 (HLA) 分子的高度多态性，它们作为宿主对几乎所有入侵病原体（包括最近新冠肺炎的病原体 SARS-CoV-2）免疫反应的关键调节因子也就不足为奇了。 -19大流行。特定 HLA 等位基因/单倍型的表达与 SARS-CoV-2 感染的易感性/进展之间已经建立了多种相关性，并且新的相关性正在不断出现。在轻度和重度疾病中都描述了保护性和有害的 HLA 变异，但考虑到现有的变异数量巨大，在如此短的时间内收集到的数据在某种程度上是令人困惑和矛盾的。这篇小型综述的目的是提供迄今为止收集到的有关 HLA-SARS-CoV-2 相互作用的主要发现的快照，以便部分解开这个错综复杂的谜团。作为 HLA 分子呈递的抗原肽生成的关键因素，ERAP1 和 ERAP2 在 SARS-CoV-2 感染中的作用也将被修改。