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At the onset of bio-complexity: microscopic devils, molecular bio-motors, and computing cells
Rendiconti Lincei. Scienze Fisiche e Naturali ( IF 1.810 ) Pub Date : 2021-05-10 , DOI: 10.1007/s12210-020-00971-1
Sergio Carrà

Nano scale motility, that is the hallmark of life, emerges when coordinated movements take over from molecular chaos. In biological world, at nanometric size, significant witnesses are present, starting from cellular traffic flows till the organized behaviors of complex molecular machines. Although their origins and evolution are still the objects of investigations, the understanding of physico-chemical mechanisms capable of extracting coordinated movements from the stochastic energy fluctuations of the surrounding liquid is improving. By accounting for the contribution due to the free energy supplied from the hydrolysis of ATP, information theory allows some meaningful in-deepments on processes and mechanisms that contribute to the increase in the complexity present in biological processes. The transfer of some engineering concepts to the biological cells shaped through a set of interacting components with functional, as well as structural relationships, evidences the presence of set-up similar to the ones conventional computers, in which the electronic circuits are able to manage logical expressions. The implications on the emergent synthetic biology are discussed, as well.



中文翻译:

生物复杂性的开始:微观魔鬼,分子生物马达和计算单元

当协调运动从分子混乱中接手时,纳米尺度的运动性便成为生命的标志。在生物世界中,从细胞流量到复杂的分子机器的有组织行为,从纳米尺度开始,都有大量的见证人出现。尽管它们的起源和演变仍然是研究的对象,但是对能够从周围液体的随机能量波动中提取协调运动的理化机理的理解正在提高。通过考虑由于ATP水解提供的自由能而产生的贡献,信息论允许对过程和机制进行一些有意义的深入研究,从而有助于增加生物过程中存在的复杂性。通过将一组工程概念转移到通过具有功能和结构关系的一组相互作用的组件而形成的生物细胞中,可以证明存在类似于传统计算机的设置,在传统计算机中,电子电路能够管理逻辑表达式。还讨论了对新兴合成生物学的影响。

更新日期:2021-05-10
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