How does the immune system tailor effector function to particular threats? Krueger et al. reveal that infection with Salmonella enterica (SE), but not with influenza A virus (IAV), drives interleukin (IL)-12-dependent outgrowth of interferon (IFN)-γ^hi type 1 T helper (Th1) cells, leading to superior protection against this phagosomal pathogen. Among these cells are ZEB2-dependent cytotoxic Th1 cells marked by CX3CR1 expression.

中文翻译：

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加强 Th1 免疫以控制吞噬体细菌

免疫系统如何针对特定威胁调整效应器功能？克鲁格等人。表明感染肠道沙门氏菌（SE），但不与A型流感病毒（IAV），白细胞介素的驱动器（IL）干扰素（IFN）-γ的-12依赖性生长^喜1型T辅助细胞（Th1）细胞，导致优异的对这种吞噬体病原体的保护。在这些细胞中，有以 CX3CR1 表达为标志的 ZEB2 依赖性细胞毒性 Th1 细胞。