The first milk sows synthesize is colostrum, and is only available to the neonate right after birth. Colostrum provides immunity, nutrients, energy, and bioactive factors which are essential for the survival, growth, and development of newborn piglets. The first few days after birth the gastrointestinal (GI) tract undergoes developmental changes and rapid growth in response to bioactive factors in milk. We hypothesized that amount of colostrum a neonate consumes the first 24 h postnatal effects the development of the GI tract. The objectives of this study were to measure the histomorphic growth of the jejunum between birth (day 0, D0) and postnatal day 7 (D7) and to determine the effect of ingesting a high versus low amount of colostrum. Gilts were identified at birth and immediately euthanized (D0, n = 6) or bottle fed a 24 h colostrum dose of 10% (COL10, n = 7) or 20% (COL20, n = 7) of birth body weight. Colostrum fed neonates were returned to birth sows after 24 h and allowed to nurse naturally until postnatal (D7), when gilts were euthanized. Gilts were dissected and jejunum was removed, weighed and placed in buffered formalin for preparation of histological sections. Five µm sections were mounted on glass slides and stained with hematoxylin and eosin (H&E). Images were captured using light microscopy at 10X magnification. ImageJ was used to measure villi length, width, stromal area, epithelial area, and crypt length. T-test analysis indicated that there was no difference between COL10 and COL20 in any of the morphological features (P > 0.05), however between D0 and D7 villi width, epithelial area, and crypt length increased (P < 0.05). Differences in histomorphology across the first week postnatal was not affected by level of colostrum intake in the first 24 h postnatal.

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49 初乳摄入日和水平对空肠发育影响的组织形态分析

第一头母猪合成的初乳是初乳，只有刚出生的新生儿才能获得。初乳提供免疫、营养、能量和生物活性因子，这些对新生仔猪的生存、生长和发育至关重要。出生后的最初几天，胃肠道 (GI) 会因牛奶中的生物活性因子而发生发育变化和快速生长。我们假设新生儿在出生后 24 小时内消耗的初乳量会影响胃肠道的发育。本研究的目的是测量出生（第 0 天，第 0 天）和出生后第 7 天（第 7 天）之间空肠的组织形态生长，并确定摄入高量和低量初乳的效果。小母猪在出生时被识别并立即实施安乐死（D0，n = 6) 或瓶喂 24 小时初乳剂量为出生体重的 10% (COL10, n = 7) 或 20% (COL20, n = 7)。初乳喂养的新生儿在 24 小时后被送回初生母猪，并让其自然哺乳直到产后 (D7)，此时后备母猪被安乐死。解剖后备母猪并取出空肠，称重并置于缓冲福尔马林中以制备组织切片。5 µm 切片安装在载玻片上，并用苏木精和伊红 (H&E) 染色。使用光学显微镜以 10 倍放大率捕获图像。ImageJ 用于测量绒毛长度、宽度、基质面积、上皮面积和隐窝长度。T 检验分析表明，COL10 和 COL20 在任何形态特征上均无差异（P > 0.05），但在 D0 和 D7 绒毛宽度、上皮面积、和隐窝长度增加（P < 0.05）。出生后第一周的组织形态学差异不受出生后前 24 小时初乳摄入水平的影响。