Two new potentiometric sensors were created for the quantification of bisoprolol fumarate and alverine citrate in bulk pharmaceutical dosage forms and human serum. Bisoprolol and alverine sensors were manufactured by combining potassium tetrakis ( p -chlorophenyl) borate ion pairs to serve as electroactive substances, plasticized poly (vinyl chloride) matrix membranes, and o -nitrophenyl octyl ether. They demonstrated high responses over the concentration ranges of 1.0×10 −6 to 1.0×10 −2 mol L −1 bisoprolol and alverine with close to Nernstian cationic slopes of 52 and 56 mV decade −1 , respectively. The detection limits for bisoprolol and alverine were 2.6×10 −6 and 1.75×10 −6 mol L −1 , respectively. For both medications, the response time was instantaneous (2.0 s). The working pH ranges for bisoprolol and alverine were 4.50–8.50 and 2.00–8.80, respectively. For both sensors, the life cycle was long (3 months). The sensors were used in pharmaceutical dosage types for the assay of bisoprolol and alverine, recording average recoveries of 99.40% and 99.98% respectively and were also successfully used for estimating the two drugs in human serum with an average recovery of 99.60% for both drugs. For all multiple staged interfering materials, the reported latest potentiometric sensor methods displayed high selectivity. The current sensor obtained a high percentage recovery and an excellent relative standard deviation compared with those obtained from previously published methods.

中文翻译：

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用于估计药物形式和人血清中比索洛尔和白藜芦醇含量的新型电位计方法

创建了两个新的电位传感器，用于定量散装药物剂型和人血清中的富马酸比索洛尔和柠檬酸白菊酯。Bisoprolol和alverine传感器是通过组合四（对氯苯基）硼酸钾离子对用作电活性物质，增塑的聚氯乙烯基质膜和邻硝基苯基辛基醚而制造的。他们在浓度范围为1.0×10 -6至1.0×10 -2 mol L -1比索洛尔和verver上显示出高响应，分别接近于Nernstian阳离子斜率，为52和56 mV October -1。比索洛尔和冰毒的检出限分别为2.6×10 -6和1.75×10 -6 mol L -1。对于这两种药物，响应时间都是瞬时的（2.0 s）。比索洛尔和盐酸的工作pH范围为4.50–8.50和2.00–8.80，分别。对于这两个传感器，生命周期都很长（3个月）。该传感器用于药物剂量类型中的比索洛尔和冰毒含量测定，分别记录平均回收率99.40％和99.98％，并且还成功地用于估计人血清中的两种药物，两种药物的平均回收率均为99.60％。对于所有多阶段干扰材料，已报道的最新电位传感器方法显示出高选择性。与从以前公布的方法获得的传感器相比，该电流传感器具有较高的回收率和出色的相对标准偏差。分别为98％且已成功用于估计人血清中的两种药物，两种药物的平均回收率均为99.60％。对于所有多阶段干扰材料，已报道的最新电位传感器方法显示出高选择性。与从以前发表的方法中获得的相比，当前传感器获得了高的百分比回收率和出色的相对标准偏差。分别为98％且已成功用于估计人血清中的两种药物，两种药物的平均回收率均为99.60％。对于所有多阶段干扰材料，已报道的最新电位传感器方法显示出高选择性。与从以前公布的方法获得的传感器相比，该电流传感器具有较高的回收率和出色的相对标准偏差。