Poor solubility limits anticancer efficiency of Artemisinin (ART). Here, two types of micronized ART products were produced in one system, using supercritical CO₂. ART microfibers (0.590 µm ± 0.160 µm) were obtained at a pressure of 25 MPa, temperature of 55 °C, and concentration of 4 mg/mL. ART microparticles (0.890 µm ± 0.610 µm) were obtained at a pressure of 20 MPa, temperature of 55 °C, and decompression time of 60 min. Importantly, the viabilities of U87 cells were 39.8% ± 2.33% and 35.3% ± 11.8%, respectively; while the viabilities of 4T1 cells were 46.2% ± 4.41% and 30.2% ± 3.74%, respectively, when treated with ART microfibers and microparticles, which could be explained by cell cycle arrest in the S phase associated with apoptotic cell induction. In conclusion, supercritical-derived ART microproducts showed improved anticancer effects.

差的溶解度限制了青蒿素（ART）的抗癌效率。在这里，使用超临界CO ₂在一个系统中生产了两种类型的微粉化ART产品。。在25 MPa的压力，55°C的温度和4 mg / mL的浓度下获得了ART超细纤维（0.590 µm±0.160 µm）。在20 MPa的压力，55°C的温度和60分钟的减压时间下获得了ART微粒（0.890 µm±0.610 µm）。重要的是，U87细胞的活力分别为39.8％±2.33％和35.3％±11.8％；当用ART超细纤维和微粒处理时，4T1细胞的活力分别为46.2％±4.41％和30.2％±3.74％，这可以用凋亡细胞诱导相关的S期细胞周期停滞来解释。总之，超临界衍生的ART微产品显示出改善的抗癌作用。