Using bioprinting and spheroid culture to create a skin model with sweat glands and hair follicles,Burns & Trauma

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Using bioprinting and spheroid culture to create a skin model with sweat glands and hair follicles
Burns & Trauma ( IF 5.3 ) Pub Date : 2021-05-04 , DOI: 10.1093/burnst/tkab013
Yijie Zhang _{1,

2} , Enhejirigala _{1,

2,

3,

4} , Bin Yao _{1,

2,

5} , Zhao Li ₁ , Wei Song _{1,

2} , Jianjun Li _{1,

2,

6} , Dongzhen Zhu _{1,

2} , Yuzhen Wang _{1,

2,

7} , Xianlan Duan _{1,

2,

8} , Xingyu Yuan _{1,

2,

8} , Sha Huang ₁ , Xiaobing Fu _{1,

2,

9}

Affiliation

Research Center for Tissue Repair and Regeneration, Medical Innovation Research Department and the Fourth Medical Center, Chinese PLA General Hospital and PLA Medical College, Beijing 100048, China.
PLA Key Laboratory of Tissue Repair and Regenerative Medicine and Beijing Key Research Laboratory of Skin Injury, Repair and Regeneration, Chinese PLA General Hospital and PLA Medical College, Beijing 100853, China.
College of Graduate, Tianjin Medical University, Tianjin 300070, China.
Institute of Basic Medical Research, Inner Mongolia Medical University, Hohhot 010110, Inner Mongolia, China.
The Shenzhen Key Laboratory of Health Sciences and Technology, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, Guangdong, China.
Department of General Surgery, the Sixth Medical Center, Chinese PLA General Hospital, Beijing 100048, China.
Department of Burn and Plastic Surgery, Air Force Hospital of Chinese PLA Central Theater Command, Datong 037000, Shanxi, China.
School of Medicine, Nankai University, Tianjin 300071, China.
Research Unit of Trauma Care, Tissue Repair and Regeneration, Chinese Academy of Medical Sciences, 2019RU051, Beijing 100048, China.

Sweat glands (SGs) and hair follicles (HFs) are two important cutaneous appendages that play crucial roles in homeostatic maintenance and thermoregulation, and their interaction is involved in wound healing. SGs can be regenerated from mesenchymal stem cell-laden 3D bioprinted scaffolds, based on our previous studies, whereas regeneration of HFs could not be achieved in the same model. Due to the lack of an in vitro model, the underlying molecular mechanism of the interaction between SGs and HFs in regeneration could not be fully understood. The purpose of the present study was to establish an in vitro model of skin constructs with SGs and HFs and explore the interaction between these two appendages in regeneration.

中文翻译：

使用生物打印和球体培养创建具有汗腺和毛囊的皮肤模型

汗腺 (SGs) 和毛囊 (HFs) 是两个重要的皮肤附属物，在稳态维持和体温调节中起关键作用，它们的相互作用参与伤口愈合。根据我们之前的研究，SGs 可以从充满间充质干细胞的 3D 生物打印支架再生，而 HFs 的再生无法在同一模型中实现。由于缺乏体外模型，SGs和HFs在再生过程中相互作用的潜在分子机制尚不清楚。本研究的目的是建立具有 SG 和 HF 的皮肤结构体外模型，并探索这两个附件在再生过程中的相互作用。

更新日期：2021-05-08

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