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Neurocognitive Heterogeneity in Social Anxiety Disorder: The Role of Self-Referential Processing and Childhood Maltreatment
Clinical Psychological Science ( IF 4.8 ) Pub Date : 2021-05-06 , DOI: 10.1177/21677026211004452
Anat Talmon 1 , Matthew Luke Dixon 1 , Philippe R. Goldin 2 , Richard G. Heimberg 3 , James J. Gross 1
Affiliation  

Social anxiety disorder (SAD) is characterized by negative self-beliefs and altered brain activation in the default-mode network (DMN). However, the extent to which there is neurocognitive heterogeneity in SAD remains unclear. We had two independent samples of patients perform a self-referential encoding task and complete self-reports of childhood maltreatment, subjective well-being, and emotion regulation. In the replication sample, we also measured DMN activation using functional MRI. We used k-means clustering, which revealed two distinct subgroups of patients with SAD in the discovery sample. Cluster 1 demonstrated higher levels of negative self-referential trait endorsement, lower levels of positive self-referential trait endorsement, and significantly higher levels of childhood emotional maltreatment, lower subjective well-being, and altered emotion-regulation-strategy use. A similar pattern was observed in the replication sample, which further demonstrated higher DMN activation during negative trait judgments in Cluster 1. Participants in the SAD clusters, from both the discovery and replication samples, were significantly distinct from samples of control participants. These findings reveal neurocognitive heterogeneity in SAD and its relationship to emotional maltreatment.



中文翻译:

在社交焦虑症中的神经认知异质性:自我参照处理和儿童虐待的作用。

社交焦虑症(SAD)的特征是负面的自我信念和默认模式网络(DMN)中的大脑激活发生改变。但是,SAD中神经认知异质性的程度仍不清楚。我们有两个独立的患者样本执行自我参照编码任务,并完成了关于儿童期虐待,主观幸福感和情绪调节的自我报告。在复制样本中,我们还使用功能性MRI测量了DMN的激活。我们用了k-均值聚类,在发现样本中揭示了SAD患者的两个不同亚组。类别1表现出较高水平的负面自我指称特质认可,较低水平的正面自我指称特质认可以及显着较高水平的儿童情感虐待,较低的主观幸福感以及改变的情绪调节策略使用。在复制样本中观察到了类似的模式,这进一步证明了在聚类1的阴性特征判断过程中DMN的活化更高。发现和复制样本中SAD聚类的参与者与对照参与者的样本明显不同。这些发现揭示了SAD中的神经认知异质性及其与情绪虐待的关系。

更新日期:2021-05-08
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