The purpose of the research was to monitor the contamination characters and spatial and temporal distributions of 23 Perfluorinated alkyl substances (PFASs) in seafood. Total of 844 samples, including 391 shellfish and 94 crustaceans, were collected from Guangdong, Guangxi, and Hainan provinces along South China Coastal Regions and analyzed by UPLC-MS/MS. Finally, 16 PFASs were detected in the survived samples and the total detection rates reached to 99.2%. The highest concentration of ∑PFASs in each sample was 28.3 μg/kg, and the average and medium values of ∑PFAS were 1.83 μg/kg and 1.18 μg/kg, respectively. Perfluorooctane sulfonic acid (PFOS) and perfluorobutyric acid (PFBA) have been considered as predominant PFAS components with the corresponding pollution contribution rates of 29.1% and 24.7%, respectively. However, it is noted that perfluorohexane sulfonate (PFNA) and perfluorobutanesulfonic acid (PFBS) were primarily enriched in the oyster and mussel. During the period of this investigation (2014–2016), ∑PFAS average concentrations turned out constantly rising trend and new pollution component perfluorohexanesulfonic acid (PFHxS) detected in 2016, indicating that the contamination status of PFASs was getting worse in South China Coastal Regions. ∑PFAS concentrations of Guangdong, Guangxi, and Hainan provinces were approximately at similar level (1.79 μg/kg, 1.91 μg/kg and 2.02 μg/kg), and the highest concentration sample contaminated with PFNA appeared in Guangxi province. The average and medium concentrations of ∑PFAS in samples collected from Guangzhou, Zhuhai, and Sanya were the top three. Safety and risk exposure assessments of perfluorooctanoic acid (PFOA) and PFOS via daily diet intakes showed relatively low potential to local residents.

该研究的目的是监测海鲜中23种全氟烷基物质（PFAS）的污染特征以及时空分布。从华南沿海地区的广东，广西和海南省共采集了844个样品，包括391个贝类和94个甲壳类动物，并通过UPLC-MS / MS进行了分析。最终，在存活的样品中检测到16种PFAS，总检出率达到99.2％。每个样品中∑PFAS的最高浓度为28.3μg/ kg，∑PFAS的平均值和中值分别为1.83μg/ kg和1.18μg/ kg。全氟辛烷磺酸（PFOS）和全氟丁酸（PFBA）被认为是主要的PFAS组分，相应的污染贡献率分别为29.1％和24.7％。然而，注意，全氟己烷磺酸盐（PFNA）和全氟丁烷磺酸（PFBS）主要富含牡蛎和贻贝。在本研究期间（2014-2016年），ΣPFAS的平均浓度呈不断上升的趋势，2016年检测到新的污染成分全氟己烷磺酸（PFHxS），这表明华南沿海地区的PFAS的污染状况日益恶化。广东，广西和海南省的∑PFAS浓度大致相近（1.79μg/ kg，1.91μg/ kg和2.02μg/ kg），广西省出现了被PFNA污染的最高浓度样品。从广州，珠海和三亚采集的样品中∑PFAS的平均和中等浓度排在前三位。