In patients with Alzheimer’s Disease (AD), the hippocampal network has been extensively investigated in previous studies; however, little is known about the morphological network associated with the hippocampus in the AD patients. A total of 68 patients with AD and another 68 gender and age matched healthy subjects were studied. Individual-level morphological hippocampal networks were constructed based on volume and texture features extracted from MRI to study the connections between bilateral hippocampus and 11 other subcortical gray matter structures. The relationship between morphological connections and Mini-Mental State Examination (MMSE) scores was also studied. Connections between bilateral hippocampus and bilateral thalamus, bilateral putamen were significant differences between the AD patients and controls (p < 0.05). There were significantly different in bilateral hippocampal connectivity, and for the left hippocampus, the connection to the right caudate were found to be statistically significant. The morphological connections between left hippocampus and bilateral thalamus (left: R = 0.371, p < 0.001; right: R = 0.411, p < 0.001), bilateral putamen (left: R = 0.383, p < 0.001; right: R = 0.348, p < 0.001), right hippocampus and bilateral thalamus (left: R = 0.370, p < 0.001; right: R = 0.387, p < 0.001), left putamen (R = 0.377, p < 0.001) were significantly positively correlated with the MMSE scores. Similar patterns were observed for left and right hippocampal connectivity and the connections highly associated with MMSE scores were also within the abnormal connections in AD patients.

在阿尔茨海默氏病（AD）患者中，先前的研究已经对海马网络进行了广泛的研究。然而，关于AD患者中与海马有关的形态网络知之甚少。共研究了68位AD患者和另外68位性别和年龄相匹配的健康受试者。基于从MRI提取的体积和纹理特征构建个人水平的海马网络，以研究双侧海马与其他11个皮层下灰质结构之间的联系。还研究了形态学联系与迷你精神状态检查（MMSE）评分之间的关​​系。双侧海马体与双侧丘脑，双侧壳状核之间的联系在AD患者和对照组之间存在显着差异（p <0.05）。双侧海马的连通性存在显着差异，对于左海马，与右尾状的连接具有统计学意义。左海马体与双侧丘脑之间的形态学联系（左：R = 0.371，p  <0.001;右：R = 0.411，p  <0.001），双侧壳壳核（左：R = 0.383，p  <0.001;右：R = 0.348，p  <0.001），右海马和双侧丘脑（左：R = 0.370，p  <0.001;右：R = 0.387，p  <0.001），左壳核（R = 0.377，p <0.001）与MMSE得分显着正相关。在左和右海马连接中观察到相似的模式，与MMSE评分高度相关的连接也处于AD患者的异常连接之内。