On March 2019 the World Health Organization declared Coronavirus disease (COVID-19) pandemic. Several recent reports disclose that the outcome of the infection is related to age, sex and can be influenced by underlying clinical conditions. Parkinson's disease (PD) and other parkinsonisms are the most common chronic disease which can cause, directly or indirectly, the patient to be more exposed to other diseases, mostly respiratory system's ones. Our primary outcome is to evaluate if PD patients are more susceptible than non-PD to take COVID-19 infection. Second, to detect if the infection course is worse in PD-COVID+ patients versus non-PD. This is a retrospective observational study on a cohort of 18 patients (13 PD- 5 non-PD), hospitalized in a Rehabilitative Unit during the occurrence of SARS-CoV2 epidemic outbreak. All patients performed laboratory tests, lung Computed Tomography (CT) and have been tested for COVID-19 thorough pharyngeal swab. PD and non-PD groups were comparable for age, gender and Hoehn and Yahr stage. Seventy-seven (77)% of PD and 60% of non-PD resulted positive for COVID-19. PD-COVID+ and PD-COVID- did not differ for age, disease duration and L-dopa daily dose. PD COVID-19+ subjects were mainly asymptomatic (50%) while non-PD ones were all symptomatic, mostly with respiratory difficulties. PD doesn't seem to be a risk factor to take SARS-COV2 infection, even if our study is related to a limited sample size. Our results, together with those of other recent studies, highlight the need to evaluate the actual susceptibility of patients with Parkinson's disease to develop COVID-19 disease, and how the infection may influence the risk of clinical worsening and increase of mortality.

中文翻译：

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SARS-COV2感染对患有帕金森氏病或帕金森氏症的寄宿患者的影响：临床病例系列研究。

2019年3月，世界卫生组织宣布冠状病毒病（COVID-19）大流行。最近的几份报告显示，感染的结果与年龄，性别有关，并且可能会受到潜在临床状况的影响。帕金森氏病（PD）和其他帕金森氏病是最常见的慢性病，​​可直接或间接导致患者更多地接触其他疾病，主要是呼吸系统疾病。我们的主要结果是评估PD患者是否比非PD患者更容易接受COVID-19感染。其次，要检测PD-COVID +患者的感染过程是否比非PD更严重。这是一项回顾性观察性研究，研究对象是SARS-CoV2流行病暴发期间在康复科住院的18例患者（13 PD-5非PD）。所有患者均进行了实验室检查，肺部计算机断层扫描（CT），并进行了COVID-19彻底咽拭子检查。PD组和非PD组在年龄，性别以及Hoehn和Yahr阶段具有可比性。七十七（77）％的PD和60％的非PD的COVID-19阳性。PD-COVID +和PD-COVID-在年龄，疾病持续时间和左旋多巴每日剂量方面没有差异。PD COVID-19 +受试者主要是无症状的（50％），而非PD则全部是有症状的，大多数患有呼吸困难。即使我们的研究与有限的样本量有关，PD似乎也不是感染SARS-COV2的危险因素。我们的研究结果以及其他最近的研究结果都强调，有必要评估帕金森氏病患者患上COVID-19疾病的实际敏感性，