The present study examined the prospective association between subjective age and epigenetic clock in 2,253 adults (Mean age = 67.40, SD = 8.17) from the Health and Retirement Study. Subjective age and demographic factors were assessed in 2008/2010 and epigenetic clock was assessed in 2016 using the DNA methylation (DNAm) PhenoAge. Regression analysis revealed that an older subjective age was associated with accelerated epigenetic aging; mediation analysis revealed that self-rated health and CRP accounted for this association. The findings indicate that individuals who feel older than their chronological age are biologically older, in part because of their perceived health and inflammatory profiles. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

中文翻译：

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主观年龄较大与表观遗传加速老化有关。

本研究调查了健康与退休研究中2,253名成年人（平均年龄= 67.40，SD = 8.17）的主观年龄与表观遗传钟之间的前瞻性关联。使用DNA甲基化（DNAm）PhenoAge在2008/2010年评估了主观年龄和人口统计学因素，并在2016年评估了表观遗传时钟。回归分析表明，主观年龄较大与表观遗传加速老化有关。调解分析显示，自我评估的健康状况和CRP是造成这种关联的原因。研究结果表明，感觉年龄超过其年龄年龄的人在生物学上年龄较大，部分原因是由于其感知的健康状况和炎症状况。（PsycInfo数据库记录（c）2021 APA，保留所有权利）。