Metal-based drugs can modulate various biological processes and exhibit a rich variety of properties that foster their use in biomedicine and chemical biology. On the way to intracellular targets, ligand exchange and redox reactions can take place, thus making metallodrug speciation in vivo a challenging task. Advances in NMR spectroscopy have made it possible to move from solution to live-cell studies and elucidate the transport of metallodrugs and interactions with macromolecular targets in a physiological setting. In turn, the electronic properties and supramolecular chemistry of metal complexes can be exploited to characterize drug delivery nanosystems by NMR. The recent evolution of in-cell NMR methodology is presented with special emphasis on metal-related processes. Applications to paradigmatic cases of platinum and gold drugs are highlighted.

中文翻译：

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核磁共振波谱研究细胞中金属药物的命运。

金属基药物可以调节各种生物过程，并具有丰富的特性，可促进其在生物医学和化学生物学中的应用。在进入细胞内靶标的过程中，可能发生配体交换和氧化还原反应，因此使体内金属药物的形成成为一项艰巨的任务。NMR光谱学的进展使得从溶液研究转向活细胞研究成为可能，并阐明了在生理环境中金属药物的运输以及与大分子靶标的相互作用。反过来，可以利用金属配合物的电子性质和超分子化学来通过NMR表征药物递送纳米系统。介绍了细胞内NMR方法的最新进展，特别强调了与金属有关的过程。