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Zinc finger proteins in the host-virus interplay: multifaceted functions based on their nucleic acid-binding property.
FEMS Microbiology Reviews ( IF 11.3 ) Pub Date : 2021-05-05 , DOI: 10.1093/femsre/fuaa059
Guanming Wang,Chunfu Zheng

Zinc finger proteins (ZFPs) are a huge family comprised of massive, structurally diverse proteins characterized by zinc ion coordinating. They engage in the host-virus interplay in-depth and occupy a significant portion of the host antiviral arsenal. Nucleic acid-binding is the basic property of certain ZFPs, which draws increasing attention due to their immense influence on viral infections. ZFPs exert multiple roles on the viral replications and host cell transcription profiles by recognizing viral genomes and host mRNAs. Their roles could be either antiviral or proviral and were separately discussed. Our review covers the recent research progress and provides a comprehensive understanding of ZFPs in antiviral immunity based on their DNA/RNA binding property.

中文翻译:

宿主-病毒相互作用中的锌指蛋白:基于其核酸结合特性的多方面功能。

锌指蛋白 (ZFP) 是一个庞大的家族,由以锌离子配位为特征的大量结构多样的蛋白质组成。它们深入参与宿主-病毒的相互作用,并占据宿主抗病毒库的很大一部分。核酸结合是某些 ZFP 的基本特性,由于它们对病毒感染的巨大影响而引起越来越多的关注。ZFP 通过识别病毒基因组和宿主 mRNA 对病毒复制和宿主细胞转录谱发挥多种作用。它们的作用可以是抗病毒或前病毒,并单独讨论。我们的综述涵盖了最近的研究进展,并根据 ZFP 的 DNA/RNA 结合特性,全面了解了抗病毒免疫中的 ZFP。
更新日期:2021-05-05
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