Zinc finger proteins (ZFPs) are a huge family comprised of massive, structurally diverse proteins characterized by zinc ion coordinating. They engage in the host-virus interplay in-depth and occupy a significant portion of the host antiviral arsenal. Nucleic acid-binding is the basic property of certain ZFPs, which draws increasing attention due to their immense influence on viral infections. ZFPs exert multiple roles on the viral replications and host cell transcription profiles by recognizing viral genomes and host mRNAs. Their roles could be either antiviral or proviral and were separately discussed. Our review covers the recent research progress and provides a comprehensive understanding of ZFPs in antiviral immunity based on their DNA/RNA binding property.

中文翻译：

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宿主病毒中的锌指蛋白相互作用：基于其核酸结合特性的多方面功能。

锌指蛋白（ZFP）是一个庞大的家族，由大量，结构多样的蛋白质组成，这些蛋白质的特征是锌离子配位。它们深入参与宿主病毒相互作用，并占据宿主抗病毒库的很大一部分。核酸结合是某些ZFP的基本特性，由于它们对病毒感染的巨大影响，核酸吸引了越来越多的关注。ZFP通过识别病毒基因组和宿主mRNA在病毒复制和宿主细胞转录谱上发挥多种作用。它们的作用可以是抗病毒的，也可以是前病毒的，并分别进行了讨论。我们的综述涵盖了最新的研究进展，并基于ZFP的DNA / RNA结合特性提供了对ZFP抗病毒免疫的全面了解。