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SARS-CoV-2 vaccine and thrombosis: Expert opinions
Thrombosis and Haemostasis ( IF 6.7 ) Pub Date : 2021-05-04 , DOI: 10.1055/a-1499-0119
Ismail Elalamy 1, 2, 3 , Grigoris Gerotziafas 1, 2 , Sonia Alamowitch 4, 5 , Jean-Pierre Laroche 6, 7 , Patrick Van Dreden 2 , Walter Ageno 8 , Jan Beyer-Westendorf 9 , Alexander T Cohen 10 , David Jimenez 11 , Benjamin Brenner 3, 12 , Saskia Middeldorp 13 , Patrice Cacoub 14, 15, 16, 17 ,
Affiliation  

Historically, the vaccination strategies developed in the second half of the 20th century have permitted to eradicate infectious diseases. From the onset of COVID-19 pandemic to March 2021, more than 141 million cases and 3 million deaths were documented worldwide with disruption of the economic and social activity, devastating material, physical and psychological consequences. Reports of unusual and severe thrombotic events, including cerebral and splanchnic venous thrombosis and other autoimmune adverse reactions such as immune thrombocytopenia or thrombotic microangiopathies (TMA) in connection with some of the SARS-CoV-2 vaccine have caused a great deal of concern within the population and the medical community. This report is intended to provide practical answers following an overview of our knowledge on these thrombotic events that are extremely rare but have serious consequences. Vaccine hesitancy threatens to reverse the progress made in controlling vaccine-preventable diseases. These adverse events must be put into perspective with an objective analysis of the facts and the issues of the vaccination strategy during this SARS-Cov-2 pandemic. Healthcare professionals remain the most pertinent advisors and influencers regarding vaccination decisions; they have to be supported in order to provide reliable and credible information on vaccines. We need to inform, reassure and support our patients when the prescription is made. Facing these challenges and these observations, a panel of experts express their insights and propose a tracking algorithm for vaccinated patients based on a10-point guideline for decision-making on what to do and not to do.

中文翻译:

SARS-CoV-2 疫苗和血栓形成:专家意见

从历史上看,20世纪下半叶制定的疫苗接种策略已经能够根除传染病。从 COVID-19 大流行爆发到 2021 年 3 月,全球记录了超过 1.41 亿例病例和 300 万人死亡,经济和社会活动受到干扰,造成了毁灭性的物质、身体和心理后果。与某些 SARS-CoV-2 疫苗相关的异常和严重血栓事件(包括脑和内脏静脉血栓形成)以及其他自身免疫性不良反应(例如免疫性血小板减少症或血栓性微血管病 (TMA))的报告引起了业内的极大关注。人口和医学界。本报告旨在概述我们对这些极其罕见但具有严重后果的血栓事件的了解,提供实用的答案。对疫苗的犹豫可能会扭转在控制疫苗可预防疾病方面取得的进展。必须客观分析本次 SARS-Cov-2 大流行期间的事实和疫苗接种策略问题,正确看待这些不良事件。医疗保健专业人员仍然是疫苗接种决策中最相关的顾问和影响者;他们必须得到支持,以便提供可靠和可信的疫苗信息。当开出处方时,我们需要告知患者、让患者放心并支持他们。面对这些挑战和观察结果,专家小组表达了他们的见解,并提出了一种针对接种疫苗的患者的跟踪算法,该算法基于关于做什么和不做什么的决策的 10 点指南。
更新日期:2021-06-25
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