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Left superior temporal sulcus morphometry mediates the impact of anxiety and depressive symptoms on sleep quality in healthy adults.
Social Cognitive and Affective Neuroscience ( IF 4.2 ) Pub Date : 2021-05-04 , DOI: 10.1093/scan/nsab012
Yanlin Wang 1 , Ping Jiang 1 , Shi Tang 1 , Lu Lu 1 , Xuan Bu 1 , Lianqing Zhang 1 , Yingxue Gao 1 , Hailong Li 1 , Xinyu Hu 1 , Song Wang 1 , Zhiyun Jia 1 , Neil Roberts 2 , Xiaoqi Huang 1, 3, 4 , Qiyong Gong 1, 3, 4
Affiliation  

Anxiety and depressive symptoms may predispose individuals to sleep disturbance. Understanding how these emotional symptoms affect sleep quality, especially the underlying neural basis, could support the development of effective treatment. The aims of the present study were therefore to investigate potential changes in brain morphometry associated with poor sleep quality and whether this structure played a mediating role between the emotional symptoms and sleep quality. One hundred and forty-one healthy adults (69 women, mean age = 26.06 years, SD = 6.36 years) were recruited. A structural magnetic resonance imaging investigation was performed, and self-reported measures of anxiety, depressive symptoms and sleep quality were obtained for each participant. Whole-brain regression analysis revealed that worse sleep quality was associated with thinner cortex in left superior temporal sulcus (STS). Furthermore, the thickness of left STS mediated the association between the emotional symptoms and sleep quality. A subsequent commonality analysis showed that physiological component of the depressive symptoms had the greatest influence on sleep quality. In conclusion, thinner cortex in left STS may represent a neural substrate for the association between anxiety and depressive symptoms and poor sleep quality and may thus serve as a potential target for neuromodulatory treatment of sleep problems.

中文翻译:

左上颞沟形态测量介导了健康成年人的焦虑和抑郁症状对睡眠质量的影响。

焦虑和抑郁症状可能使个体容易出现睡眠障碍。了解这些情绪症状如何影响睡眠质量,尤其是潜在的神经基础,可以支持有效治疗的发展。因此,本研究的目的是调查与睡眠质量差相关的大脑形态测量的潜在变化,以及这种结构是否在情绪症状和睡眠质量之间起中介作用。招募了一百四十一名健康成人(69名妇女,平均年龄= 26.06岁,SD = 6.36岁)。进行了结构磁共振成像研究,并为每个参与者获得了自我报告的焦虑,抑郁症状和睡眠质量的测量值。全脑回归分析显示,较差的睡眠质量与左上颞沟(STS)皮层变薄有关。此外,左STS的厚度介导了情绪症状与睡眠质量之间的关联。随后的共性分析表明,抑郁症状的生理成分对睡眠质量的影响最大。总之,左STS中较薄的皮质可能代表了焦虑和抑郁症状与不良睡眠质量之间联系的神经底物,因此可以作为神经调节治疗睡眠问题的潜在靶标。随后的共性分析表明,抑郁症状的生理成分对睡眠质量的影响最大。总之,左STS中较薄的皮质可能代表了焦虑和抑郁症状与不良睡眠质量之间的关联的神经基质,因此可以作为神经调节治疗睡眠问题的潜在靶标。随后的共性分析表明,抑郁症状的生理成分对睡眠质量的影响最大。总之,左STS中较薄的皮质可能代表了焦虑和抑郁症状与不良睡眠质量之间的关联的神经基质,因此可以作为神经调节治疗睡眠问题的潜在靶标。
更新日期:2021-05-04
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