ABSTRACT

While photochemical oxidants (O_x = O₃+ NO₂) are known to increase asthma flare-ups, there is a paucity of studies of the Japanese population, especially for Tokyo residents. We used data on asthma cases (n = 7,455) from ambulance dispatches in Tokyo, 2015–2016. Variables included date and time of incidence, age, sex, occurrence location at the ward (ku) level, and the symptom/cause of dispatch as recorded by paramedics. O_x data were obtained from the nearest air quality monitoring station to the occurrence location, then linked them with the outcomes based on occurrence date. We directly incorporated a distributed lag model into a bi-directional case-crossover study design controlling for ambient temperature and day of week. A 10-ppb increase in O_x for lag days 0–3 was associated with a 5.51% (95% CI: 0.13 to 11.18) increase in ambulance dispatches related to asthma. The association was strongest on lag day 1 (4.67%, 95% CI: 0.51 to 9.00). Exposure to high levels of O_x was associated with increased ambulance dispatches related to asthma exacerbations in Tokyo, Japan.

摘要

虽然已知光化学氧化剂（O _x  = O ₃ + NO ₂）会增加哮喘发作，但对日本人群，尤其是东京居民的研究很少。我们使用了 2015-2016 年东京救护车调度的哮喘病例数据（n = 7,455）。变量包括发病日期和时间、年龄、性别、病房 ( ku ) 级别的发生地点以及护理人员记录的派遣症状/原因。氧_{_}从离发生地点最近的空气质量监测站获取数据，然后根据发生日期将其与结果联系起来。我们直接将分布式滞后模型纳入控制环境温度和星期几的双向案例交叉研究设计。在第0-3 天，O _x增加 10 ppb与哮喘相关的救护车调度增加 5.51%（95% CI：0.13 至 11.18）相关。该关联在滞后第 1 天最强（4.67%，95% CI：0.51 至 9.00）。在日本东京，暴露于高水平的 Ox_与增加与哮喘恶化相关的救护车调度有关。