BACKGROUND Several markers that influence the clinical course of atopic dermatitis (AD) have been investigated so far. Thymus and activation regulated chemokine (TARC) - a Th2-related cytokine - increase in various atopic diseases. It has been shown that vitamin D affects Treg cells and immune responses. Zinc as an essential trace element for cell-cell interactions, cellular differentiation, and proliferation. However, the effect of these markers on infantile AD and disease severity are mostly unknown. OBJECTIVE The aim of this study was to investigate the relationship between TARC, vitamin D, zinc levels, and the disease severity in infants with AD. METHOD AD patients (n = 160) with age and sex that matched healthy controls (n = 79) were included in the study. The diagnosis of AD was made based on the Hanifin-Rajka criteria. The objective SCORAD index was used for the assessment of disease severity. RESULTS A total of 160 patients (male 71.9%) with AD were included in the study. The median age of onset of symptoms was 2 (1.0-3.5) months. The lesions initially started on face 76.9%, neck 6.9%, extremities 7.5%, and body 8.8%. Nearly 40% of the patients were found to be atopic. Food allergy was found in 39.4%. The median of objective SCORAD index was 27.5 (17.5-40) in the study group. The TARC levels of AD patients were higher than control group [1803 pg/ml (1006- 3123) vs 709 pg/ml (504-1147), p < 0.001] There was a significant correlation between objective SCORAD scores and TARC values in subjects with AD (r = 0.363, p < 0.001). As the severity of AD increased, vitamin D levels decreased (p for trend 0.015) and TARC values increased (p for trend < 0.001). Serum zinc levels did not change with the severity of the disease. The presence of atopy did not have an influence on serum TARC, zinc, and vitamin D levels. CONCLUSION In infants with AD, disease severity is positively related with TARC levels; and inversely proportional to vitamin D levels. TARC levels differ between patients and healthy controls. The presence of atopy has not been shown to affect these markers. © 2021 Codon Publications. Published by Codon Publications.

中文翻译：

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小儿特应性皮炎：血清维生素D，锌和TARC水平及其与疾病表型和严重程度的关系。

背景技术迄今为止，已经研究了几种影响特应性皮炎（AD）临床病程的标志物。胸腺和激活调节趋化因子（TARC）-Th2相关的细胞因子-在各种特应性疾病中均增加。已经显示维生素D影响Treg细胞和免疫反应。锌是细胞间相互作用，细胞分化和增殖所必需的微量元素。然而，这些标记物对婴儿AD和疾病严重程度的影响大多是未知的。目的本研究的目的是调查TARC，维生素D，锌水平与AD婴儿疾病严重程度之间的关系。方法本研究纳入了年龄和性别与健康对照组（n = 79）相匹配的AD患者（n = 160）。AD的诊断是根据Hanifin-Rajka标准进行的。客观的SCORAD指数用于评估疾病的严重程度。结果本研究共纳入160例AD患者（男性71.9％）。症状发作的中位年龄为2（1.0-3.5）个月。皮损最初从面部76.9％，颈部6.9％，四肢7.5％和身体8.8％开始。发现将近40％的患者患有特应性。发现食物过敏者占39.4％。研究组的客观SCORAD指数中位数为27.5（17.5-40）。AD患者的TARC水平高于对照组[1803 pg / ml（1006- 3123）vs 709 pg / ml（504-1147），p <0.001]受试者的客观SCORAD评分与TARC值之间存在显着相关性AD（r = 0.363，p <0.001）。随着AD严重程度的增加，维生素D含量降低（趋势0.015的p）和TARC值升高（趋势<0.001的p）。血清锌水平并未随疾病的严重程度而改变。特应性的存在对血清TARC，锌和维生素D水平没有影响。结论AD患儿的疾病严重程度与TARC水平呈正相关。与维生素D水平成反比。患者和健康对照者的TARC水平不同。尚未显示特应性的存在会影响这些标志物。©2021 Codon Publications。由Codon Publications发布。尚未显示特应性的存在会影响这些标志物。©2021 Codon Publications。由Codon Publications发布。尚未显示特应性的存在会影响这些标志物。©2021 Codon Publications。由Codon Publications发布。