INTRODUCTION AND OBJECTIVE The oral food challenge (OFC) is the gold standard to diagnose food allergy (FA); however, it is not a procedure free from the risk of having significant allergic reactions, even life-threatening.The aims of our study were to evaluate the frequency of positive OFCs performed in children with a suspected diagnosis of IgE- and non-IgE-mediated (food protein-induced enterocolitis syndrome (FPIES)) FA and how the failed challenges were managed. MATERIALS AND METHODS A retrospective chart review was done on all children who have had OFCs in a tertiary-care pediatric allergy unit from 2017 to 2019. RESULTS 682 patients were enrolled and 2206 challenges were performed: 2058 (93%) for IgE-mediated FA and 148 (7%) for FPIES. There were 262 (11.8%) challenge failures. The transfer to the emergency department was required 3 times (1.1%). None of the failed challenges resulted in death or hospitalization and 13.3% challenges did not require any treatment. CONCLUSIONS Our findings confirm that food challenges can be performed safely in a specialized setting by well-trained personnel; all food challenge reactions, even the most serious, were reversible, thanks to a prompt recognition and treatment that generally did not worsen over time.

中文翻译：

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在一家三级儿科医院的过敏病房中，积极的口服食物挑战的频率及其结果。

引言和目标 口服食物激发试验（OFC）是诊断食物过敏（FA）的金标准。然而，这并不是一个没有严重过敏反应风险甚至危及生命的手术。我们研究的目的是评估在疑似诊断为 IgE 和非 IgE 的儿童中进行阳性 OFC 的频率介导的（食物蛋白诱导的小肠结肠炎综合征 (FPIES)）FA 以及如何管理失败的挑战。材料和方法 对 2017 年至 2019 年在三级保健儿科过敏病房中患有 OFC 的所有儿童进行回顾性图表审查。结果 682 名患者入组并进行了 2206 次挑战：2058 名 (93%) 为 IgE 介导的 FA和 148 (7%) 用于 FPIES。有 262 次 (11.8%) 挑战失败。需要转移到急诊室 3 次 (1.1%)。没有一次失败的挑战导致死亡或住院，13.3% 的挑战不需要任何治疗。结论 我们的研究结果证实，训练有素的人员可以在专门的环境中安全地执行食物挑战；所有食物挑战反应，即使是最严重的，都是可逆的，这要归功于及时的识别和治疗，通常不会随着时间的推移而恶化。