Forskolin, a class of labdane-type diterpenoid, has significant medicinal value in anticancer, antiasthmatic, antihypertensive, and heart-strengthening treatments. The main source of natural forskolin is its extraction from the cork tissue of the root of Coleus forskohlii. However, conventional modes of extraction pose several challenges. In recent years, the construction of microbial cell factories to produce medicinal natural products via synthetic biological methods has effectively solved the current problems and is a research hotspot in this field. This review summarizes the recent progress in the heterologous synthesis of forskolin via synthetic biological technology, analyzes the current challenges, and proposes corresponding strategies.

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毛喉素异源生物合成研究进展

毛喉素是一类拉丹丹型二萜类化合物，在抗癌、平喘、降压、强心等方面具有重要的药用价值。天然毛喉素的主要来源是从毛喉锦紫苏根的软木组织中提取。然而，传统的提取模式提出了一些挑战。近年来，建设微生物细胞工厂，通过合成生物方法生产药用天然产物，有效解决了当前的问题，是该领域的研究热点。本文综述了合成生物技术异源合成毛喉素的最新进展，分析了当前面临的挑战，并提出了相应的策略。