Forskolin, a class of labdane-type diterpenoid, has significant medicinal value in anticancer, antiasthmatic, antihypertensive, and heart-strengthening treatments. The main source of natural forskolin is its extraction from the cork tissue of the root of Coleus forskohlii. However, conventional modes of extraction pose several challenges. In recent years, the construction of microbial cell factories to produce medicinal natural products via synthetic biological methods has effectively solved the current problems and is a research hotspot in this field. This review summarizes the recent progress in the heterologous synthesis of forskolin via synthetic biological technology, analyzes the current challenges, and proposes corresponding strategies.

中文翻译：

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佛司可林的异源生物合成研究进展。

Forskolin是一类拉丹烷型二萜类化合物，在抗癌，平喘，降压和增强心脏的治疗中具有重要的医学价值。天然毛喉素的主要来源是从彩叶锦葵根的软木组织中提取的。但是，传统的提取方式带来了一些挑战。近年来，通过合成生物方法生产药物天然产物的微生物细胞工厂的建设有效地解决了当前的问题，并且是该领域的研究热点。这篇综述总结了通过合成生物技术异源合成佛司可林的最新进展，分析了当前面临的挑战，并提出了相应的策略。