Intricate relationships between endocytosis and cellular signaling, first recognized nearly 40 years ago through the study of tyrosine kinase growth factor receptors, are now known to exist for multiple receptor classes and to affect myriad physiological and developmental processes. This review summarizes our present understanding of how endocytosis orchestrates cellular signaling networks, with an emphasis on mechanistic underpinnings and focusing on two receptor classes-tyrosine kinase and G protein-coupled receptors-that have been investigated in particular detail. Together, we believe that these examples provide a useful survey of the current consensus, uncertainties, and controversies in this rapidly advancing area of cell biology. Expected final online publication date for the Annual Review of Biochemistry, Volume 90 is June 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

中文翻译：

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通过内吞作用调节和组织受体信号传导的机制。

内吞作用与细胞信号转导之间的复杂关系，是近40年前通过对酪氨酸激酶生长因子受体的研究首次认识到的，现在已知存在于多种受体类别中，并影响着无数的生理和发育过程。这篇综述总结了我们目前对内吞作用如何协调细胞信号传导网络的理解，重点是机理基础，并着重研究了两个受体类别-酪氨酸激酶和G蛋白偶联受体-已进行了特别详细的研究。总之，我们相信这些例子为在这个迅速发展的细胞生物学领域中当前的共识，不确定性和争议提供了有用的调查。《生物化学年度评论》第90卷的最终最终在线发布日期为2021年6月。