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The influence of rs53576 polymorphism in the oxytocin receptor (OXTR) gene on empathy in healthy adults by subtype and ethnicity: a systematic review and meta-analysis
Reviews in the Neurosciences ( IF 4.1 ) Pub Date : 2021-04-23 , DOI: 10.1515/revneuro-2021-0038 Russell J Chander 1 , Karen A Mather 1, 2 , Rhiagh Cleary 1 , Sarah A Grainger 3 , Anbupalam Thalamuthu 1 , Katya Numbers 1 , Nicole A Kochan 1 , Nicola J Armstrong 1, 4 , Henry Brodaty 1, 5 , Julie D Henry 3 , Perminder S Sachdev 1, 6
Reviews in the Neurosciences ( IF 4.1 ) Pub Date : 2021-04-23 , DOI: 10.1515/revneuro-2021-0038 Russell J Chander 1 , Karen A Mather 1, 2 , Rhiagh Cleary 1 , Sarah A Grainger 3 , Anbupalam Thalamuthu 1 , Katya Numbers 1 , Nicole A Kochan 1 , Nicola J Armstrong 1, 4 , Henry Brodaty 1, 5 , Julie D Henry 3 , Perminder S Sachdev 1, 6
Affiliation
Empathy is essential for navigating complex social environments. Prior work has shown associations between rs53576, a single nucleotide polymorphism (SNP) located in the oxytocin receptor gene (OXTR ), and generalized empathy. We undertook a systematic review and meta-analysis to assess the effects of rs53576 on subdomains of empathy, specifically cognitive empathy (CE) and affective empathy (AE), in healthy adults. Twenty cohorts of 8933 participants aged 18–98 were identified, including data from the Sydney Memory and Ageing Study, a cohort of older community adults. Meta-analyses found G homozygotes had greater generalized empathic abilities only in young to middle-aged adults. While meta-analyses of empathy subdomains yielded no significant overall effects, there were differential effects based on ethnicity. G homozygotes were associated with greater CE abilities in Asian cohorts (standardized mean difference; SMD: 0.09 [2.8·10−3 –0.18]), and greater AE performance in European cohorts [SMD: 0.12 (0.04–0.21)]. The current literature highlights a need for further work that distinguishes between genetic and ethnocultural effects and explores effects of advanced age on this relationship.
中文翻译:
催产素受体 (OXTR) 基因中 rs53576 多态性对亚型和种族健康成人移情的影响:系统评价和荟萃分析
同理心对于驾驭复杂的社会环境至关重要。先前的研究表明,rs53576 是一种位于催产素受体基因中的单核苷酸多态性 (SNP)。OXTR ) 和广义的同理心。我们进行了系统回顾和荟萃分析,以评估 rs53576 对健康成年人共情子域的影响,特别是认知共情 (CE) 和情感共情 (AE)。确定了 20 个队列,共 8933 名年龄在 18-98 岁之间的参与者,其中包括来自悉尼记忆和衰老研究的数据,这是一个社区老年人队列。荟萃分析发现,G 纯合子仅在青年到中年人中具有更强的泛化共情能力。虽然移情子域的荟萃分析没有产生显着的总体影响,但存在基于种族的不同影响。在亚洲人群中,G 纯合子与更高的 CE 能力相关(标准化平均差;SMD:0.09 [2.8·10-3 –0.18]),以及欧洲队列中更高的 AE 性能 [SMD:0.12 (0.04–0.21)]。目前的文献强调需要进一步的工作来区分遗传和民族文化的影响,并探索高龄对这种关系的影响。
更新日期:2021-04-23
中文翻译:
催产素受体 (OXTR) 基因中 rs53576 多态性对亚型和种族健康成人移情的影响:系统评价和荟萃分析
同理心对于驾驭复杂的社会环境至关重要。先前的研究表明,rs53576 是一种位于催产素受体基因中的单核苷酸多态性 (SNP)。