Evaluating associations between the five-factor personality domains and resting-state functional connectivity networks (e.g. default mode network, DMN) highlights distributed neurobiological systems linked to behaviorally relevant phenotypes. Establishing these associations can highlight a potential underlying role for these neural pathways in related clinical illness and treatment response. Here, we examined associations between within- and between-network resting-state functional connectivity with functional magnetic resonance imaging and the five-factor personality domains: Openness to experience (Openness), Extraversion, Neuroticism, Agreeableness and Conscientiousness. We included data from 470 resting-state scan sessions and personality assessments in 295 healthy participants. Within- and between-network functional connectivity from 32 a priori defined regions was computed across seven resting-state networks. The association between functional connectivity and personality traits was assessed using generalized least squares. Within-network DMN functional connectivity was significantly negatively associated with trait Openness (regression coefficient = −0.0010; [95% confidence interval] = [−0.0017, −0.0003]; PFWER = 0.033), seemingly driven by association with the Fantasy subfacet. Trait Extraversion was significantly negatively associated with functional connectivity between the visual and dorsal attention networks and positively associated with functional connectivity between the frontoparietal and language networks. Our findings provide evidence that resting-state DMN is associated with trait Openness and gives insight into personality neuroscience.

中文翻译：

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默认模式网络功能连接与特征开放性负相关

评估五因素人格域和静息状态功能连接网络（例如默认模式网络，DMN）之间的关联突出了与行为相关表型相关的分布式神经生物学系统。建立这些关联可以突出这些神经通路在相关临床疾病和治疗反应中的潜在潜在作用。在这里，我们检查了网络内和网络间静息状态功能连接与功能磁共振成像和五因素人格域之间的关联：体验开放性（开放性）、外向性、神经质、宜人性和尽责性。我们纳入了来自 295 名健康参与者的 470 次静息状态扫描和性格评估的数据。在七个静息状态网络中计算了来自 32 个先验定义区域的网络内和网络间功能连接。使用广义最小二乘法评估功能连接性和人格特征之间的关联。网络内 DMN 功能连接与特征开放性显着负相关（回归系数 = -0.0010；[95% 置信区间] = [-0.0017, -0.0003]；PFWER = 0.033），似乎是由与幻想子方面的关联驱动的。特质外向性与视觉和背侧注意网络之间的功能连接呈显着负相关，与额顶和语言网络之间的功能连接呈正相关。