BACKGROUND Nowadays, moisturizers contain non-steroidal anti-inflammatory agents that help for treatment of atopic dermatitis (AD). Defensil® (black currant seed oil, sunflower oil, and balloon vine), a new anti-inflammatory, obtained from plant extracts, remain had a few studies for AD. OBJECTIVE To compare the effectiveness of moisturizer containing 3% Defensil®, 5% dexpanthenol and ceramide (LDC) with 5% urea cream in childhood AD treatment. METHODS Thirty-eight patients with diagnosis of atopic dermatitis by UK working party's criteria were recruited in randomized, controlled, double-blinded 4-week study. The patients were received with twice-daily application of LDC cream on one side of the body and 5% urea cream on the opposite side. The clinical severity was assessed by modified scoring of atopic dermatitis (SCORAD). Median time to remission was analyzed by survival analysis. RESULTS Thirty-seven out of 38 patients accomplished the protocol. The clinical SCORAD significantly improved from baseline in both groups (p < 0.001) after 2 and 4 weeks. Furthermore, the LDC group significantly reduced severity of disease better than the 5% urea group (P = 0.043). The mean difference SCORAD scores were -13.83 (±1.83) and -13.04 (±3.22) respectively. Stratum corneum hydration (SCH) was enhanced from baseline in both groups (p < 0.001) but no statistically significant difference between both groups. Median time to remission had no statistically significant difference (P = 0.697). CONCLUSIONS The effectiveness of LDC cream is better than 5% urea cream for improving clinical atopic dermatitis. It was suggested that moisturizer containing LDC could be used for the treatment of mild-to-moderate childhood atopic dermatitis.

中文翻译：

---

包含亚油酸，5％泛醇和神经酰胺的乳膏，用于治疗特应性皮炎。

背景技术如今，保湿剂包含有助于治疗特应性皮炎（AD）的非甾体抗炎药。从植物提取物中获得的新型抗炎药Defensil®（黑加仑子油，葵花籽油和球囊葡萄藤）仍对AD进行了一些研究。目的比较含3％Defensil®，5％泛醇和神经酰胺（LDC）的保湿剂与5％尿素乳霜在儿童AD治疗中的功效。方法根据英国工作组的标准，对38例诊断为特应性皮炎的患者进行了随机，对照，双盲，为期4周的研究。患者每天在身体的一侧每天服用两次LDC乳膏，在另一侧每天使用5％的尿素乳膏。通过改良特应性皮炎评分（SCORAD）评估临床严重程度。通过生存分析来分析中位缓解时间。结果38例患者中有37例完成了方案。2周和4周后，两组的临床SCORAD均较基线显着改善（p <0.001）。此外，LDC组比5％尿素组显着降低了疾病的严重程度（P = 0.043）。SCORAD评分的平均差异分别为-13.83（±1.83）和-13.04（±3.22）。两组的角质层水合（SCH）均较基线增强（p <0.001），但两组之间无统计学差异。中位缓解时间无统计学差异（P = 0.697）。结论LDC乳膏在改善临床特应性皮炎方面优于5％尿素乳膏。