The SARS-CoV-2 coronavirus pandemic calls for coordinated efforts by the scientific community for the development of vaccines. The most advanced strategies have focused on modifications of technologies that were already under development for other viruses, such as SARS, MERS, and even Influenza. Classic and new technologies, such as inactivated and attenuated viruses (non-replicative and replicative), DNA and mRNA vaccines, and nanoparticles containing SARS-CoV-2 antigens, are some of the strategies currently investigated. Although there is a very high expectation for the effectiveness of the most advanced vaccine candidates, there are still no established correlates of protection. Previous experience in vaccine development for other pathogens shows that differences in vaccine formulation can result in diverse immune responses and consequently, different protective properties. Therefore the importance of continuing investigations on a broad range of strategies. Expertise in vaccine development in Brazil was refocused to the new coronavirus. Impressive collaboration between institutions will support further developments until we have available a safe, effective, and economically viable vaccine. Established competence and collaborations will allow preparedness for future challenges and can also be used to address local issues as neglected infectious diseases.

中文翻译：

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SARS-CoV-2疫苗的开发以及巴西的贡献。

SARS-CoV-2冠状病毒大流行呼吁科学界为疫苗的开发做出协调一致的努力。最先进的策略集中于对其他病毒（例如SARS，MERS甚至是流感）正在开发的技术进行修改。目前正在研究一些经典和新技术，例如灭活和减毒病毒（非复制型和复制型），DNA和mRNA疫苗以及含有SARS-CoV-2抗原的纳米颗粒。尽管人们对最先进的候选疫苗的功效寄予很高的期望，但仍然没有确定的保护关联。以前在针对其他病原体的疫苗开发中的经验表明，疫苗配方的差异会导致多种免疫反应，因此，不同的防护性能。因此，继续研究各种策略的重要性。巴西疫苗开发方面的专业知识重新聚焦于新的冠状病毒。机构之间的令人印象深刻的合作将支持进一步的发展，直到我们获得安全，有效和经济上可行的疫苗为止。既定的能力和合作关系将为应对未来的挑战做好准备，也可用于解决被忽视的传染病等当地问题。和经济上可行的疫苗。既定的能力和合作关系将为应对未来的挑战做好准备，也可用于解决被忽视的传染病等当地问题。和经济上可行的疫苗。既定的能力和合作关系将为应对未来的挑战做好准备，也可用于解决被忽视的传染病等当地问题。