The chromatin structure is dynamically regulated by many different modulators that post-translationally modify histones, replace canonical histones with histone variants, and unwind nucleosomal DNA, thereby modulating the accessibility of nucleosomal DNA and facilitating downstream DNA-templated nuclear processes. To understand how these modulators change the chromatin structure, it is essential to determine the 3D structures of chromatin modulators in complex with nucleosome. Here, we review the very recent progress in structural studies of some selected chromatin modulators in complex with nucleosome, including those of histone demethylases LSD1/2, some pioneer transcription factors, and the PWWP domain-containing protein LEDGF.

中文翻译：

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染色质调节剂与核小体复合的结构。

染色质结构由许多不同的调节剂动态调节，这些调节剂在翻译后修饰组蛋白，用组蛋白变体取代规范的组蛋白，释放核小体DNA，从而调节核小体DNA的可及性，并促进下游DNA模板化的核过程。要了解这些调节剂如何改变染色质结构，必须确定与核小体复合的染色质调节剂的3D结构。在这里，我们审查了与核小体复合的某些选定染色质调节剂的结构研究的最新进展，包括组蛋白脱甲基酶LSD1 / 2，一些先驱转录因子和含PWWP结构域的蛋白质LEDGF。