Metastases are the main cause of cancer-related mortality in breast cancer. Although significant progress has been made in the field of tumor metastasis, the exact molecular mechanisms involved in tumor metastasis are still unclear. Here, we report that ATOH8-V1, a novel isoform of ATOH8, is highly expressed in breast cancer and is a negative prognostic indicator of survival for patients. Forced expression of ATOH8-V1 dramatically enhances, while silencing of ATOH8-V1 decreases the metastasis of breast cancer cell lines. Moreover, ATOH8-V1 directly binds to the RhoC promoter and stimulates the expression of RhoC, which in turn enhances the metastasis of breast cancer. Altogether, our data demonstrate that ATOH8-V1 is a novel pro-metastatic factor that enhances cancer metastasis, suggesting that ATOH8-V1 is a potential therapeutic target for treatment of metastatic cancers.

中文翻译：

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一种新的 ATOH8 异构体通过调节 RhoC 促进乳腺癌的转移。

转移是乳腺癌癌症相关死亡的主要原因。尽管在肿瘤转移领域取得了重大进展，但涉及肿瘤转移的确切分子机制仍不清楚。在这里，我们报告 ATOH8-V1 是一种新的 ATOH8 同种型，在乳腺癌中高度表达，是患者生存的阴性预后指标。ATOH8-V1 的强制表达显着增强，而 ATOH8-V1 的沉默减少了乳腺癌细胞系的转移。此外，ATOH8-V1直接与RhoC启动子结合，刺激RhoC的表达，进而促进乳腺癌的转移。总之，我们的数据表明 ATOH8-V1 是一种新的促进癌症转移的促转移因子，