To systemically evaluate the efficacy and safety of Maxing Shigan Decoction in the treatment of community acquired pneumonia(CAP) and provide a reference for the treatment of CAP. Databases of CNKI, Wanfang, VIP, SinoMed, EMbase, Cochrane Library, Web of Science and PubMed were searched(from inception to May 30, 2020) to screen the randomized controlled trials(RCTs) of Maxing Shigan Decoction in treating CAP. Two authors independently screened and selected relevant literature and extracted data based on the inclusion and exclusion criteria. Any disagreement or differences was resolved through discussion. The bias risk assessment tool recommended by Cochrane handbook was used to evaluate the quality of the included studies, and RevMan 5.3 software was used for data analysis. Seventeen RCTs were finally included, involving 1 309 patients. Meta-analysis showed that Maxing Shigan Decoction combined with conventional Western medicine treatment could improve clinical efficacy in patients with CAP more effectively as compared with conventional Western medicine treatment alone, mainly in terms of anti-inflammatory effects, a decrease in C-reactive protein(CRP) content(MD=-6.01, 95%CI[-10.95,-1.06], P=0.02)and white blood cell(WBC) count, a decrease in procalcitonin(PCT) level(MD=-0.74, 95%CI[-0.77,-0.71], P<0.000 1), and shortened recovery time of cough and fever. Maxing Shigan Decoction has certain curative effect on CAP, but there are problems in the methodology of included studies. High-quality stu-dies are still needed for further verification.

中文翻译：

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麻杏石甘汤治疗社区获得性肺炎随机对照试验的系统评价。

系统评价麻杏石甘汤治疗社区获得性肺炎(CAP)的疗效和安全性，为CAP的治疗提供参考。检索CNKI、万方、VIP、SinoMed、EMbase、Cochrane图书馆、Web of Science和PubMed数据库（从建库至2020年5月30日），筛选麻杏石甘汤治疗CAP的随机对照试验（RCT）。两位作者根据纳入和排除标准独立筛选和选择相关文献并提取数据。任何分歧或分歧均通过讨论解决。采用Cochrane手册推荐的偏倚风险评估工具评价纳入研究的质量，采用RevMan 5.3软件进行数据分析。最终纳入 17 项 RCT，涉及 1 309 名患者。Meta分析显示，麻杏石甘汤联合西药常规治疗较单纯西药常规治疗能更有效地提高CAP患者的临床疗效，主要表现在抗炎作用、C反应蛋白降低（ CRP）含量（MD=-6.01, 95%CI[-10.95,-1.06], P=0.02）和白细胞（WBC）计数，降钙素原（PCT）水平降低（MD=-0.74, 95%CI [-0.77,-0.71]，P<0.000 1)，缩短咳嗽和发热的恢复时间。麻杏石甘汤对CAP有一定疗效，但纳入研究的方法学存在问题。仍然需要高质量的研究来进一步验证。