ABSTRACT

Introduction

Compared with traditional cancer treatment methods, tumor-targeted immunotherapy can combine targeted therapy and immunotherapy with long-lasting responses to achieve synergistic therapy, which brings hope to the complete cure of cancer.

Areas covered

This review summarizes the newest and most up-to-date advances in tumor-targeted immunotherapy, including tumor-associated macrophages (TAMs) targeted immunotherapy, regulatory T (Treg) cells targeted immunotherapy, tumor-associated fibroblasts (TAFs) targeted immunotherapy and immune checkpoints targeted immunotherapy.

Expert opinion

Immunotherapy can restore anti-tumor immunity in the tumor microenvironment and produce a lasting immune surveillance effect. Smart multifunctional nano delivery system can effectively combine targeted therapy with immunotherapy, which has attracted extensive attention. With the deepening of research, more and more tumor-targeted immunotherapy enter into the clinical trial phases, especially antibodies and inhibitors. Tumor-targeted immunotherapy is a promising approach for conquering cancer and bringing hope for human health.

中文翻译：

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肿瘤靶向免疫治疗研究进展

摘要

介绍

与传统的癌症治疗方法相比，肿瘤靶向免疫治疗可以将靶向治疗和免疫治疗相结合，实现协同治疗，为癌症的彻底治愈带来希望。

覆盖区域

本综述总结了肿瘤靶向免疫治疗的最新进展，包括肿瘤相关巨噬细胞（TAMs）靶向免疫治疗、调节性 T（Treg）细胞靶向免疫治疗、肿瘤相关成纤维细胞（TAFs）靶向免疫治疗和免疫治疗。检查点靶向免疫治疗。

专家意见

免疫治疗可以恢复肿瘤微环境中的抗肿瘤免疫，产生持久的免疫监视作用。智能多功能纳米给药系统可将靶向治疗与免疫治疗有效结合，受到广泛关注。随着研究的深入，越来越多的肿瘤靶向免疫疗法进入临床试验阶段，尤其是抗体和抑制剂。肿瘤靶向免疫疗法是一种很有前途的方法，可以战胜癌症，为人类健康带来希望。