Metabolism is essential for a living organism to sustain life. It provides energy to a cell by breaking down compounds (catabolism) and supplies building blocks for the synthesis of macromolecules (anabolism). Signal transduction pathways tightly regulate mammalian cellular metabolism. Simultaneously, metabolism itself serves as a signaling pathway to control many cellular processes, such as proliferation, differentiation, cell death, gene expression, and adaptation to stress. Considerable progress in the metabolism field has come from understanding how cancer cells co-opt metabolic pathways for growth and survival. Recent data also show that several metabolic pathways may participate in the pathogenesis of lung diseases, some of which could be promising therapeutic targets. In this translational review, we will outline the basic metabolic principles learned from the cancer metabolism field as they apply to the pathogenesis of pulmonary arterial hypertension and fibrosis and will place an emphasis on therapeutic potential.

新陈代谢对于生物体维持生命至关重要。它通过分解化合物（分解代谢）为细胞提供能量，并为大分子的合成（合成代谢）提供构件。信号转导途径紧密调节哺乳动物细胞代谢。同时，新陈代谢本身作为信号通路来控制许多细胞过程，例如增殖、分化、细胞死亡、基因表达和对压力的适应。代谢领域的巨大进步来自于对癌细胞如何利用代谢途径进行生长和生存的了解。最近的数据还表明，几种代谢途径可能参与肺部疾病的发病机制，其中一些可能是有希望的治疗靶点。在这篇翻译评论中，