Both preclinical and clinical studies have pointed that aerobic exercise, at moderate doses, is beneficial at all stages of life by promoting a range of physiological and neuroplastic adaptations that reduce the anxiety response. Previous research about this topic has repeatedly described how the regular practice of aerobic exercise induces a positive regulation of neuroplasticity and neurogenesis-related genes, as well as a better control of the HPA axis function. However, limited progress has been carried out in the integration of neuroendocrine and neuroplastic changes, as well as in introducing new factors to understand how aerobic exercise can promote resilience to future stressful conditions. Resilience is defined as the ability to adapt to stress while maintaining healthy mental and physical performance. Consistent findings point to an important role of FKBP5, the gene expressing FK506-binding protein 51 (FKBP51), as a strong inhibitor of the glucocorticoid receptor (GR), and thus, an important regulator of the stress response. We propose that aerobic exercise could contribute to modulate FKBP5 activity acting as a potential therapeutic approach for mood disorders. In this sense, aerobic exercise is well known for increasing the growth factor BDNF, which by downstream pathways could affect the FKBP5 activity. Therefore, our manuscript has the aim of analyzing how FKBP5 could constitute a promising target of aerobic exercise promoting resilient-related phenotypes.

临床前和临床研究都指出，中等剂量的有氧运动通过促进一系列生理和神经可塑性适应来减少焦虑反应，对生命的各个阶段都有益。先前关于该主题的研究反复描述了有氧运动的常规练习如何诱导神经可塑性和神经发生相关基因的正调节，以及更好地控制 HPA 轴功能。然而，在整合神经内分泌和神经可塑性变化以及引入新因素以了解有氧运动如何促进对未来压力条件的恢复方面进展有限。复原力被定义为在保持健康的心理和身体表现的同时适应压力的能力。一致的研究结果表明 FKBP5 的重要作用，即表达 FK506 结合蛋白 51 (FKBP51) 的基因，作为糖皮质激素受体 (GR) 的强抑制剂，因此是应激反应的重要调节剂。我们提出有氧运动可能有助于调节 FKBP5 活性，作为情绪障碍的潜在治疗方法。从这个意义上说，有氧运动以增加生长因子 BDNF 而闻名，其通过下游途径可能影响 FKBP5 活性。因此，我们的手稿旨在分析 FKBP5 如何构成有氧运动的有希望的目标，从而促进弹性相关表型。应激反应的重要调节剂。我们提出有氧运动可能有助于调节 FKBP5 活性，作为情绪障碍的潜在治疗方法。从这个意义上说，有氧运动以增加生长因子 BDNF 而闻名，其通过下游途径可能影响 FKBP5 活性。因此，我们的手稿旨在分析 FKBP5 如何构成有氧运动的有希望的目标，从而促进弹性相关表型。应激反应的重要调节剂。我们提出有氧运动可能有助于调节 FKBP5 活性，作为情绪障碍的潜在治疗方法。从这个意义上说，有氧运动以增加生长因子 BDNF 而闻名，其通过下游途径可能影响 FKBP5 活性。因此，我们的手稿旨在分析 FKBP5 如何构成有氧运动的有希望的目标，从而促进弹性相关表型。