The fusion of secretory vesicles with the plasma membrane depends on the assembly of v-SNAREs (VAMP2/synaptobrevin2) and t-SNAREs (SNAP25/syntaxin1) into the SNARE complex. Vesicles go through several upstream steps, referred to as docking and priming, to gain fusion competence. The vesicular protein synaptotagmin-1 (Syt-1) is the principal Ca2+ sensor for fusion in several central nervous system neurons and neuroendocrine cells and part of the docking complex for secretory granules. Syt-1 binds to the acceptor complex such as synaxin1, SNAP-25 on the plasma membrane to facilitate secretory vesicle docking, and upon Ca2+-influx promotes vesicle fusion. This review assesses the role of the Syt-1 protein involved in the secretory vesicle docking, priming, and fusion.

中文翻译：

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Synaptotagmin-1：一种多功能蛋白，介导囊泡对接，引物和融合。

分泌囊泡与质膜的融合取决于将v-SNARE（VAMP2 / synaptobrevin2）和t-SNARE（SNAP25 / syntaxin1）组装到SNARE复合物中。囊泡经历数个上游步骤，称为对接和灌注，以获得融合能力。囊泡蛋白突触结合蛋白1（Syt-1）是主要的Ca2 +传感器，可在多个中枢神经系统神经元和神经内分泌细胞中融合，并且是分泌颗粒对接复合体的一部分。Syt-1结合到质膜上的受体复合物，如synaxin1，SNAP-25，以促进分泌性囊泡对接，并且在Ca2 +流入时促进囊泡融合。这篇综述评估了Syt-1蛋白在分泌性小泡对接，引发和融合中的作用。