The evolution of the nucleus is an evolutionary milestone. By enabling genome compartmentalization, it contributes to the fine-tuning of genome functions. The genome is partitioned into functional domains differing in spatial positioning and topological folding at different scales. The rise of '3D Genomics' embracing experimental, theoretical, and modeling approaches allowed the proposal of a multiscale model of the eukaryotic genome, capturing its organizing principles and functionalities. In these efforts, resolving causality remains an important objective. Are positioning and folding the cause or consequence of functional states? This minireview presents emerging answers to this question, borrowing examples from recent studies of the three-dimensional genome in both plants and animals.

中文翻译：

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表观遗传调控中的三维基因组组织：原因还是结果？

细胞核的进化是进化的里程碑。通过启用基因组划分，它有助于基因组功能的微调。基因组被划分为在不同尺度上空间定位和拓扑折叠不同的功能域。包含实验、理论和建模方法的“3D 基因组学”的兴起允许提出真核基因组的多尺度模型，捕捉其组织原理和功能。在这些努力中，解决因果关系仍然是一个重要目标。定位和折叠是功能状态的原因还是结果？这篇小综述提供了这个问题的新答案，借用了最近对植物和动物三维基因组研究的例子。