Huntington’s disease (HD) is a genetic, inexorably fatal neurodegenerative disease. Patient average survivability is up to 20 years after the onset of symptoms. Those who suffer from the disease manifest motor, cognitive, and psychiatric impairments. There is indirect evidence suggesting that omega-3 polyunsaturated fatty acids (ω-3 PUFA) could have alleviating effects on most of HD symptoms. These include beneficial effects against cachexia and weight loss, decrease of cognitive impairment over time, and improvement of psychiatric symptoms such as depression and irritability. Furthermore, there is a positive correlation between consumption of ω-3 PUFAs in diets and prevalence of HD, as well as direct effects on the disease via release of serotonin. Unfortunately, to date, very few studies have examined the effects of ω-3 PUFAs in HD, both on the symptoms and on disease progression. This paper reviews evidence in the literature suggesting that ω-3 PUFAs can be used in neurodegenerative disorders. This information can be extrapolated to support further research of ω-3 PUFAs and their potential use for HD treatment.

中文翻译：

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支持 omega-3 多不饱和脂肪酸作为亨廷顿病症状的潜在疗法的汇聚证据

亨廷顿舞蹈病 (HD) 是一种遗传性的、致命的神经退行性疾病。症状出现后，患者的平均生存能力可达 20 年。患有这种疾病的人表现出运动、认知和精神障碍。有间接证据表明 omega-3 多不饱和脂肪酸 (ω-3 PUFA) 可以缓解大多数 HD 症状。这些包括对恶病质和体重减轻的有益作用，随着时间的推移认知障碍的减少，以及精神症状如抑郁和易怒的改善。此外，饮食中 ω-3 多不饱和脂肪酸的摄入量与 HD 患病率之间存在正相关关系，以及对疾病的直接影响通过血清素的释放。不幸的是，迄今为止，很少有研究检查 HD 中 ω-3 多不饱和脂肪酸对症状和疾病进展的影响。本文回顾了文献中表明 ω-3 PUFA 可用于神经退行性疾病的证据。可以推断该信息以支持对 ω-3 PUFA 的进一步研究及其在 HD 治疗中的潜在用途。