Extracellular vesicles (EVs) are a heterogeneous group of cell-derived membranous vesicles secreted by various cells in the extracellular space. Accumulating evidence shows that EVs regulate cell-to-cell communication and signaling in the pathological processes of various diseases by carrying proteins, lipids, and nucleic acids to recipient cells. Glia-derived EVs act as a double-edged sword in the pathogenesis of central nervous system (CNS) diseases. They may be vectors for the spread of diseases or act as effective clearance systems to protect tissues. In this review, we summarize recent studies on glia-derived EVs with a focus on their relationships with CNS diseases.

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神经胶质细胞外囊泡在中枢神经系统疾病中的作用：更新

细胞外囊泡 (EVs) 是由细胞外空间中的各种细胞分泌的一组异质的细胞衍生膜囊泡。越来越多的证据表明，电动汽车通过将蛋白质、脂质和核酸运送到受体细胞来调节各种疾病病理过程中的细胞间通讯和信号传导。神经胶质细胞衍生的 EV 在中枢神经系统 (CNS) 疾病的发病机制中是一把双刃剑。它们可能是疾病传播的载体，也可能是保护组织的有效清除系统。在这篇综述中，我们总结了最近关于神经胶质细胞衍生 EV 的研究，重点是它们与 CNS 疾病的关系。