PURPOSE Understanding how religion and spirituality influence health-related quality of life (HRQoL) is important for developing holistic, patient-centered treatment. This study determined distinct latent classes of religiousness/spirituality for adult persons living with HIV (PLWH) and associations between latent class membership and HRQoL. METHODS Baseline data was collected from 223 patients in the FAmily CEntered (FACE) Advance Care Planning (ACP) clinical trial for PLWH. Patients completed the Brief Multidimensional Measurement of Religiousness/Spirituality (BMMRS-adapted), Patient Health Questionnaire (PHQ-9), Medical Outcome Study-HIV Survey (MOS-HIV) and the Palliative care Outcome Scale (POS). The optimal number of latent classes was determined by comparing K-Class model with (K-1)-Class model iteratively. The relationship between latent class membership, HRQoL and demographic characteristics was assessed. RESULTS Patients were 56.1% male, 86.1% Black/African American, aged 22-77 (Mean=50.83). 75.3% were Christian. LCA identified three classes: traditionally religious (35%), privately religious (47.1%), and spiritual but not religious (17.9%). MOS-HIV mental health (p < 0.001), MOS-HIV quality of life (p = 0.014) and MOS-HIV health transition (p = 0.016) scores were significantly higher among patients who were traditionally religious. These patients were more likely to be 40+ years and Black. Patients in the privately religious group had the lowest levels of mental health and HRQoL. CONCLUSIONS Understanding how religiousness and spirituality influence HRQoL can help the medical community develop holistic, patient-centered and culturally-sensitive interventions that could improve outcomes for PLWH and potentially mitigate the impact of health disparities within the Black and LGBTQ communities.

中文翻译：

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宗教和灵性在 HIV 感染者健康相关生活质量中的作用：潜在阶级分析。

目的 了解宗教和灵性如何影响与健康相关的生活质量 (HRQoL) 对于开发以患者为中心的整体治疗非常重要。本研究确定了成年 HIV 感染者 (PLWH) 的不同的潜在宗教/灵性类别以及潜在类别成员身份与 HRQoL 之间的关联。方法 基线数据是从 PLWH 的 FAmily CEntered (FACE) 预先护理计划 (ACP) 临床试验中的 223 名患者中收集的。患者完成了宗教/灵性的简要多维测量（BMMRS-adapted）、患者健康问卷（PHQ-9）、医学结果研究-HIV 调查（MOS-HIV）和姑息治疗结果量表（POS）。通过迭代比较 K-Class 模型和 (K-1)-Class 模型来确定潜在类别的最佳数量。评估了潜在班级成员、HRQoL 和人口统计学特征之间的关系。结果 患者为 56.1% 的男性，86.1% 的黑人/非裔美国人，年龄在 22-77 岁（平均值 = 50.83）。75.3% 是基督徒。LCA 确定了三个类别：传统宗教（35%）、私人宗教（47.1%）和精神但非宗教（17.9%）。传统宗教信仰患者的 MOS-HIV 心理健康 (p < 0.001)、MOS-HIV 生活质量 (p = 0.014) 和 MOS-HIV 健康转变 (p = 0.016) 得分明显更高。这些患者更有可能是 40 岁以上的黑人。私人宗教团体的患者心理健康和 HRQoL 水平最低。结论 了解宗教和灵性如何影响 HRQoL 可以帮助医学界全面发展，