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Perspectives and Advances in the Understanding of Tuberculosis.
Annual Review of Pathology: Mechanisms of Disease ( IF 36.2 ) Pub Date : 2021-01-24 , DOI: 10.1146/annurev-pathol-042120-032916
Rachel L Kinsella 1 , Dennis X Zhu 1 , Gregory A Harrison 1 , Anne E Mayer Bridwell 1 , Jerome Prusa 1 , Sthefany M Chavez 1 , Christina L Stallings 1
Affiliation  

Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), remains a leading cause of death due to infection in humans. To more effectively combat this pandemic, many aspects of TB control must be developed, including better point of care diagnostics, shorter and safer drug regimens, and a protective vaccine. To address all these areas of need, better understanding of the pathogen, host responses, and clinical manifestations of the disease is required. Recently, the application of cutting-edge technologies to the study of Mtb pathogenesis has resulted in significant advances in basic biology, vaccine development, and antibiotic discovery. This leaves us in an exciting era of Mtb research in which our understanding of this deadly infection is improving at a faster rate than ever, and renews hope in our fight to end TB. In this review, we reflect on what is known regarding Mtb pathogenesis, highlighting recent breakthroughs that will provide leverage for the next leaps forward in the field.

中文翻译:

认识结核病的观点和进展。

结核分枝杆菌(TB)是结核病(TB)的病原体,仍然是人类感染的主要死亡原因。为了更有效地抵抗这种大流行,必须开发结核病控制的许多方面,包括更好的现场诊断,更短和更安全的药物治疗方案以及保护性疫苗。为了解决所有这些需求领域,需要对病原体,宿主反应和疾病的临床表现有更好的了解。最近,尖端技术在Mtb发病机理研究中的应用已在基础生物学,疫苗开发和抗生素发现方面取得了重大进展。这使我们处于Mtb研究的激动人心的时代,在这个时代,我们对这种致命感染的了解正在以前所未有的速度提高,并为我们终结结核病的斗争重新燃起了希望。
更新日期:2021-01-24
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